Bruton’s tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor
signaling in the development and functioning of adaptive immunity. Growing evidence also …

Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high
levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to …

Chitin is the second most abundant polysaccharide in nature and linked to fungal infection
and asthma. However, bona fide immune receptors directly binding chitin and signaling …

The pore-forming inflammatory cell death pathway, pyroptosis, was first described in the early
1990s and its role in health and disease has been intensively studied since. The effector …

The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a
fascinating cellular machinery endowed with the capacity for rapid proteolytic processing of the …

Staphylococcus aureus is a facultative pathogen found on skin and nasal surfaces. It is usually
absent from the skin of healthy humans but frequently colonizes the skin of patients with …

Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily
by skin lesions with massive infiltration of leukocytes, but frequently also presents with …

Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by
accessory proteins, posttranslational modifications, cellular localization, and oligomerization. …

The next generation of COVID-19 vaccines needs to broaden the antigenic repertoire to
improve breadth of immune response and efficacy against emerging variants of concern. This …

Background: Inflammation is a double-edged state of immune activation that is required to
resolve threats harmful to the host but can also cause severe collateral damage. …