[HTML][HTML] Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the …
Rationale There are controversial pieces of evidence whether combination therapies using
memantine and cholinesterase inhibitors are beneficial over their monotreatments. However, …
memantine and cholinesterase inhibitors are beneficial over their monotreatments. However, …
[HTML][HTML] Single mild traumatic brain injury induces persistent disruption of the blood-brain barrier, neuroinflammation and cognitive decline in hypertensive rats
Traumatic brain injury (TBI) induces blood-brain barrier (BBB) disruption, which contributes
to secondary injury of brain tissue and development of chronic cognitive decline. However, …
to secondary injury of brain tissue and development of chronic cognitive decline. However, …
[HTML][HTML] Cognitive enhancer effects of low memantine doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in …
ZK Bali, N Bruszt, SA Tadepalli, R Csurgyók… - Frontiers in …, 2019 - frontiersin.org
Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and
memory and are promising targets for pharmacological cognitive enhancement. Memantine, an …
memory and are promising targets for pharmacological cognitive enhancement. Memantine, an …
[HTML][HTML] Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse …
Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum
roots have been employed in traditional oriental herbal medicine, however, their mechanisms …
roots have been employed in traditional oriental herbal medicine, however, their mechanisms …
[HTML][HTML] Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats
Repetitive mild traumatic brain injuries (TBI) impair cognitive abilities and increase risk of
neurodegenerative disorders in humans. We developed two repetitive mild TBI models in rats …
neurodegenerative disorders in humans. We developed two repetitive mild TBI models in rats …
[HTML][HTML] Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A Longitudinal in vivo Diffusion Tensor Imaging Study
Background: Stress-induced cellular changes in limbic brain structures contribute to the
development of various psychopathologies. In vivo detection of these microstructural changes …
development of various psychopathologies. In vivo detection of these microstructural changes …
Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats
Pharmacological and functional data suggest the existence of uridine (Urd) receptors in the
central nervous system (CNS). In the present study, simultaneous extracellular single unit …
central nervous system (CNS). In the present study, simultaneous extracellular single unit …
[HTML][HTML] Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine …
Alpha7 nicotinic acetylcholine receptors (nAChRs) are promising novel targets for the treatment
of neurocognitive disorders. Although the cognitive enhancer potential of alpha7 nAChR …
of neurocognitive disorders. Although the cognitive enhancer potential of alpha7 nAChR …
[HTML][HTML] Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor …
Age-related neurocognitive disorders are common problems in developed societies. Aging
not only affects memory processes, but may also disturb attention, vigilance, and other …
not only affects memory processes, but may also disturb attention, vigilance, and other …
Converging Evidence on D-Amino Acid Oxidase–Dependent Enhancement of Hippocampal Firing Activity and Passive Avoidance Learning in Rats
… Zsolt Kristóf Bali , Zsolt Kristóf Bali … We thank Kristóf Kelemen for his help in data analysis
of the behavioral results and Katalin Kónya for her assistance in passive avoidance tests. …
of the behavioral results and Katalin Kónya for her assistance in passive avoidance tests. …