User profiles for Zsuzsanna Ament
 | Zsuzsanna AmentResearch Fellow, HMS MGH Verified email at mgh.harvard.edu Cited by 1071 |
Metabolic basis to Sherpa altitude adaptation
…, BO Fernandez, SL Burgess, Z Ament… - Proceedings of the …, 2017 - National Acad Sciences
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life
in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen …
in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen …
[PDF][PDF] Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (ie, nonalcoholic
fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, …
fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, …
[HTML][HTML] Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance
…, S Chiu, PH Pan, SY Lin, E Stanley, Z Ament… - Scientific reports, 2017 - nature.com
Recent findings have shown an inverse association between circulating C15: 0/C17: 0 fatty
acids with disease risk, therefore, their origin needs to be determined to understanding their …
acids with disease risk, therefore, their origin needs to be determined to understanding their …
[HTML][HTML] Mechanisms of vascular dysfunction in COPD and effects of a novel soluble epoxide hydrolase inhibitor in smokers
Background Smoking and COPD are risk factors for cardiovascular disease, and the
pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-…
pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-…
Myc expression drives aberrant lipid metabolism in lung cancer
MYC-mediated pathogenesis in lung cancer continues to attract interest for new therapeutic
strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung …
strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung …
[HTML][HTML] Integration of metabolomics, lipidomics and clinical data using a machine learning method
Background The recent pandemic of obesity and the metabolic syndrome (MetS) has led to
the realisation that new drug targets are needed to either reduce obesity or the subsequent …
the realisation that new drug targets are needed to either reduce obesity or the subsequent …
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and
fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting …
fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting …
Plasma metabolites link dietary patterns to stroke risk
Objective While dietary intake is linked to stroke risk, surrogate markers that could inform
personalized dietary interventions are lacking. We identified metabolites associated with diet …
personalized dietary interventions are lacking. We identified metabolites associated with diet …
Machine learning-driven metabolomic evaluation of cerebrospinal fluid: insights into poor outcomes after aneurysmal subarachnoid hemorrhage
BACKGROUND Aneurysmal subarachnoid hemorrhage (aSAH) is associated with a high
mortality and poor neurologic outcomes. The biologic underpinnings of the morbidity and …
mortality and poor neurologic outcomes. The biologic underpinnings of the morbidity and …
[HTML][HTML] A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy
Metabolomics can be performed either as an ‘open profiling’tool where the aim is to measure,
usually in a semi-quantitative manner, as many metabolites as possible or perform ‘closed’…
usually in a semi-quantitative manner, as many metabolites as possible or perform ‘closed’…