Continuing improvements in analytical technology along with an increased interest in
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …

Chronic obstructive pulmonary disease (COPD) is a major source of morbidity, mortality, and
costs in the Western world (1). In the United States, for example, COPD is responsible for …

Rationale: Lung dysbiosis promotes airway inflammation and decreased local immunity,
potentially playing a role in the pathogenesis of acute exacerbations of chronic obstructive …

Aims Exosome-mediated microRNA transfer is a recently discovered mode of cell-to-cell
communication, in which microRNAs act as paracrine molecules, exerting their regulatory …

BACKGROUND Up-to-date estimates of burden of diseases are required for evidence-based
decision-making. The objectives of this study were to determine the excess costs of COPD …

Acute graft rejection is an important clinical problem in renal transplantation and an adverse
predictor for long term graft survival. Plasma biomarkers may offer an important option for …

Background Identifying non-invasive and reliable blood-derived biomarkers for early detection
of acute cellular rejection in heart transplant recipients is of great importance in clinical …

Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and
mortality in the world. Regrettably, there are no biomarkers to objectively diagnose COPD …

There is a great interest in developing biomarkers to enable precision medicine and improve
health outcomes of patients with COPD. However, biomarker development is extremely …

Background The impact of airway hyperreactivity (AHR) on respiratory mortality and systemic
inflammation among patients with chronic obstructive pulmonary disease (COPD) is largely …