User profiles for Zuoshang Xu
 | Zuoshang XuProfessor of Biochemistry and Molecular Pharmacology, University of Massachusetts … Verified email at umassmed.edu Cited by 18548 |
[HTML][HTML] Asymmetry in the assembly of the RNAi enzyme complex
A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex
that mediates target RNA cleavage. Here, we show that the two strands of an siRNA duplex …
that mediates target RNA cleavage. Here, we show that the two strands of an siRNA duplex …
Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration, skeletal muscle
atrophy, paralysis, and death. Mutations in Cu,Zn superoxide dismutase (SOD1) are one cause …
atrophy, paralysis, and death. Mutations in Cu,Zn superoxide dismutase (SOD1) are one cause …
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Z Xu, LC Cork, JW Griffin, DW Cleveland - Cell, 1993 - cell.com
Excessive accumulation of neurofilaments in the cell bodies and proximal axons of motor
neurons is a major pathological hallmark during the early stages of many human motor neuron …
neurons is a major pathological hallmark during the early stages of many human motor neuron …
Neurofilaments are obligate heteropolymers in vivo
Neurofilaments (NFs), composed of three distinct subunits NF-L, NF-M, and NF-H, are
neuron-specific intermediate filaments present in most mature neurons. Using DNA transfection …
neuron-specific intermediate filaments present in most mature neurons. Using DNA transfection …
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.
Mutation in superoxide dismutase 1 (SOD1), a Cu/Zn enzyme that removes oxygen radicals
and protects against oxidative injury, has been implicated in some cases of familial …
and protects against oxidative injury, has been implicated in some cases of familial …
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
…, C Guégan, M Nagai, Z Xu… - Proceedings of the …, 2006 - National Acad Sciences
Mutation in superoxide dismutase-1 (SOD1), which is a cause of ALS, alters the folding
patterns of this protein. Accumulation of misfolded mutant SOD1 might activate endoplasmic …
patterns of this protein. Accumulation of misfolded mutant SOD1 might activate endoplasmic …
Reactive astrocytes secrete lcn2 to promote neuron death
…, G Qiu, B Huang, Q Wu, F Li, Z Xu… - Proceedings of the …, 2013 - National Acad Sciences
Glial reaction is a common feature of neurodegenerative diseases. Recent studies have
suggested that reactive astrocytes gain neurotoxic properties, but exactly how reactive …
suggested that reactive astrocytes gain neurotoxic properties, but exactly how reactive …
[HTML][HTML] Several rAAV vectors efficiently cross the blood–brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
Noninvasive systemic gene delivery to the central nervous system (CNS) has largely been
impeded by the blood–brain barrier (BBB). Recent studies documented widespread CNS …
impeded by the blood–brain barrier (BBB). Recent studies documented widespread CNS …
[HTML][HTML] Designing siRNA that distinguish between genes that differ by a single nucleotide
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a
powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain…
powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain…
[HTML][HTML] ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation …
CMJ Higgins, C Jung, Z Xu - BMC neuroscience, 2003 - Springer
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the
intermembrane space and by involvement of SOD1 aggregation and peroxisomes | BMC …
intermembrane space and by involvement of SOD1 aggregation and peroxisomes | BMC …