[HTML][HTML] A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling …

…, Q Wang, S Xiao, A Li, Y Xie, J Li, X Zhao, Z He… - BMC genomics, 2010 - Springer
Background MicroRNAs (miRNAs) are a large class of tiny non-coding RNAs (~22-24 nt) that
regulate diverse biological processes at the posttranscriptional level by controlling mRNA …

Genetic evidence of 'genuine' empty follicle syndrome: a novel effective mutation in the LHCGR gene and review of the literature

P Yuan, Z He, L Zheng, W Wang, Y Li… - Human …, 2017 - academic.oup.com
Empty follicle syndrome (EFS) is a reproductive disorder in which no oocytes are retrieved
during IVF. The existence of genuine EFS (GEFS) is still controversial, and to date, only one …

[HTML][HTML] Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness

…, Y Zhang, L Qin, Y Niu, Y Guo, X Liu, P Cong, Z He… - PloS one, 2011 - journals.plos.org
Understanding the dynamics of muscle transcriptome during development and between
breeds differing in muscle growth is necessary to uncover the complex mechanism underlying …

[HTML][HTML] Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing

S Xiao, J Jia, D Mo, Q Wang, L Qin, Z He, X Zhao… - PloS one, 2010 - journals.plos.org
Porcine reproductive and respiratory syndrome (PRRS) has been one of the most economically
important diseases affecting swine industry worldwide and causes great economic …

[HTML][HTML] Highly efficient generation of pigs harboring a partial deletion of the CD163 SRCR5 domain, which are fully resistant to porcine reproductive and respiratory …

C Guo, M Wang, Z Zhu, S He, H Liu, X Liu… - Frontiers in …, 2019 - frontiersin.org
Porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2 differ in their
recognition of CD163. Substitution of porcine CD163 SRCR5 domain with a human CD163-like …

Highly efficient targeted chromosome deletions using CRISPR/Cas9

Z He, C Proudfoot, AJ Mileham… - Biotechnology and …, 2015 - Wiley Online Library
The CRISPR/Cas9 system has emerged as an intriguing new technology for genome
engineering. It utilizes the bacterial endonuclease Cas9 which, when delivered to eukaryotic cells …

Lipopolysaccharide‐induced miR‐1224 negatively regulates tumour necrosis factor‐α gene expression by modulating Sp1

…, X Zhao, X Wang, S Xiao, Q Wang, Y Xie, Z He… - …, 2011 - Wiley Online Library
The innate immune response provides the initial defence mechanism against infection by
other organisms. However, an excessive immune response will cause damage to host tissues. …

Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs

…, R Li, J Zeng, D Mo, P Cong, X Liu, Y Chen, Z He - Transgenic …, 2019 - Springer
Insulin-like growth factor 2 (IGF2) plays an important role in the development of the foetus
and in post-natal growth and development. A SNP within intron 3 of porcine IGF2 disrupts a …

Precise editing of myostatin signal peptide by CRISPR/Cas9 increases the muscle mass of Liang Guang Small Spotted pigs

…, X Shi, J Zeng, L Yang, D Mo, X Liu, Y Chen, Z He - Transgenic …, 2020 - Springer
Myostatin (MSTN), a member of the transforming growth factor-β superfamily, is a negative
regulator of muscle growth and development. Disruption of the MSTN gene in various …

[HTML][HTML] KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors

Q Zhu, F Liang, S Cai, X Luo, T Duo, Z Liang, Z He… - Cell death & …, 2021 - nature.com
Histone lysine demethylase 4A (KDM4A) plays a crucial role in regulating cell proliferation,
cell differentiation, development and tumorigenesis. However, little is known about the …