The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist
administration represent an experimental approach of persisting interest. These models were …

Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals
between the IP 3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central …

Endoplasmic reticulum-mitochondria contacts (ERMCs) are restructured in response to changes
in cell state. While this restructuring has been implicated as a cause or consequence of …

Mitochondrial Ca 2+ elevations enhance ATP production, but uptake must be balanced by
efflux to avoid overload. Uptake is mediated by the mitochondrial Ca 2+ uniporter channel …

Background: Cardiac contractile function requires high energy from mitochondria, and Ca 2+
from the sarcoplasmic reticulum (SR). Via local Ca 2+ transfer at close mitochondria-SR …

The use of fixed fibroblasts from familial and sporadic Alzheimer's disease patients has
previously indicated an upregulation of mitochondria–ER contacts (MERCs) as a hallmark of …

Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS)
is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase …

Reference ranges provide a powerful tool for diagnostic decision-making in clinical medicine
and are enormously valuable for understanding normality in pre-clinical scientific research …

Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+
release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match …

Aims Endoplasmic reticulum (ER) stress has recently emerged as an important mechanism
involved in the pathogenesis of cardiovascular diseases. However, the molecular …