Regulation of the X Chromosomes in Caenorhabditis elegans
- 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064
- 2Department of Biology, Emory University, Atlanta, Georgia 30322
- 3Department of Biology and Center for Genomics and Systems Biology, New York University, New York, New York 10003
- 4Department of Biology and Carolina Center for Genome Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
- Correspondence: sstrome{at}ucsc.edu
Abstract
Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.
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