Diversity of Neural Precursors in the Adult Mammalian Brain
- Michael A. Bonaguidi1,2,3,7,
- Ryan P. Stadel1,4,
- Daniel A. Berg1,2,
- Jiaqi Sun1,5,
- Guo-li Ming1,2,3,6 and
- Hongjun Song1,2,3,4,6
- 1Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
- 2Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
- 3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
- 4Human Genetics Predoctoral Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
- 5School of Life Sciences, Tsinghua University, Beijing 100084, China
- 6The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
- Correspondence: mbonagui{at}usc.edu
Abstract
Aided by advances in technology, recent studies of neural precursor identity and regulation have revealed various cell types as contributors to ongoing cell genesis in the adult mammalian brain. Here, we use stem-cell biology as a framework to highlight the diversity of adult neural precursor populations and emphasize their hierarchy, organization, and plasticity under physiological and pathological conditions.
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