Antigen Receptor Signaling to NF-κB via CARMA1, BCL10, and MALT1
- Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
- Correspondence: margot.thomemiazza{at}unil.ch
Abstract
The signaling pathway controlling antigen receptor-induced regulation of the transcription factor NF-κB plays a key role in lymphocyte activation and development and the generation of lymphomas. Work of the past decade has led to dramatic progress in the identification and characterization of new players in the pathway. Moreover, novel enzymatic activities relevant for this pathway have been discovered, which represent interesting drug targets for immuno-suppression or lymphoma treatment. Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future.
Footnotes
-
Editors: Lawrence E. Samelson and Andrey Shaw
-
Additional Perspectives on Immunoreceptor Signaling available at www.cshperspectives.org
- Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
