Role of Yeast SNF and SWI Proteins in Transcriptional Activation
This extract was created in the absence of an abstract.
Excerpt
Activated transcription by eukaryotic RNA polymerase II requires general transcription factors and enhancer-binding activator proteins. Activators are thought to have roles in stabilizing or accelerating the assembly of the general transcription factors and in counteracting the repressive effects of histones (for review, see Kornberg and Lorch 1992; Zawel and Reinberg 1993). Other classes of intermediary proteins termed coactivators and co-antirepressors are often required (see Croston et al. 1992; Gill and Tjian 1992).
In the yeast Saccharomyces cerevisiae the SNF/SWI proteins appear to play vital intermediary roles in stimulating transcription of many diversely regulated genes, and their function may be conserved among eukaryotes (for review, see Winston and Carlson 1992). This group of proteins includes SNF2/SWI2, SNF5, SNF6, SWI1, and SWI3. SNF2, SNF5, and SNF6 (sucrose nonfermenting) were first identified genetically as positive regulators of the gene encoding invertase, SUC2 (Neigeborn and Carlson 1984), and the SWI1, SWI2, and SWI3 proteins...
