A structure-based model of RIG-I activation

Daniel Kolakofsky; Eva Kowalinski; Stephen Cusack

doi:10.1261/rna.035949.112

A structure-based model of RIG-I activation

¹Department of Microbiology and Molecular Medicine, University of Geneva School of Medicine, CMU, 1211 Geneva, Switzerland
²Max-Planck Institute for Biochemistry, 82142 Martinsried, Germany
³European Molecular Biology Laboratory, Grenoble Outstation and UJF-EMBL-CNRS International Unit of Virus Host-Cell Interactions, BP181, 38042 Grenoble Cedex 9, France

Abstract

A series of high-resolution crystal structures of RIG-I and RIG-I:dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.

Keywords

RIG-I activation; dsRNA PAMPs; crystal and cocrystal X-ray structures

Footnotes

↵4 Corresponding author

E-mail daniel.kolakofsky{at}unige.ch
Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.035949.112.