Galaxy: A platform for interactive large-scale genome analysis
- Belinda Giardine1,
- Cathy Riemer1,
- Ross C. Hardison1,
- Richard Burhans1,
- Laura Elnitski2,
- Prachi Shah1,2,
- Yi Zhang1,
- Daniel Blankenberg1,
- Istvan Albert1,
- James Taylor1,
- Webb Miller1,
- W. James Kent3, and
- Anton Nekrutenko1,4
- 1 Center for Comparative Genomics and Bioinformatics, Huck Institutes for Life Sciences, Penn State University, University Park, Pennsylvania 16802, USA
- 2 National Human Genome Research Institute, Bethesda, Maryland 20892, USA
- 3 Department of Computer Science and Engineering, University of California at Santa Cruz, Santa Cruz, California 95064, USA
Abstract
Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.
Footnotes
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[Supplemental material is available online at www.genome.org.]
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Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.4086505. Article published online before print in September 2005.
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↵4 Corresponding author. E-mail anton{at}bx.psu.edu; fax (814) 863-6699.
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- Accepted July 6, 2005.
- Received May 3, 2005.
- Cold Spring Harbor Laboratory Press
