Histone H2B ubiquitination: the cancer connection

Joaquín M. Espinosa

doi:10.1101/gad.1732108

Histone H2B ubiquitination: the cancer connection

Joaquín M. Espinosa1

Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA

Abstract

Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664– 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.

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Footnotes

↵1 Correspondence.

↵1 E-MAIL Joaquin.espinosa{at}colorado.edu; FAX (303) 492-7744.
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1732108.