(ADP-ribosyl)hydrolases: structure, function, and biology
- 1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;
- 2Institute for the Experimental Endocrinology and Oncology, National Research Council of Italy, 80145 Naples, Italy
- Corresponding author: ivan.ahel{at}path.ox.ac.uk
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↵3 These authors contributed equally to this work.
Abstract
ADP-ribosylation is an intricate and versatile posttranslational modification involved in the regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives from the varied range of different chemical linkages, including to several amino acid side chains as well as nucleic acids termini and bases, it can adopt. In this review, we provide an overview of the different families of (ADP-ribosyl)hydrolases. We discuss their molecular functions, physiological roles, and influence on human health and disease. Together, the accumulated data support the increasingly compelling view that (ADP-ribosyl)hydrolases are a vital element within ADP-ribosyl signaling pathways and they hold the potential for novel therapeutic approaches as well as a deeper understanding of ADP-ribosylation as a whole.
Keywords
- macrodomain
- ARH3
- DraG
- catalytic mechanism
- structural biology
- genome stability
- ADP-ribose
- ADP-ribosylation
- DNA damage
- PARG
- PARP
Footnotes
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Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.334631.119.
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Freely available online through the Genes & Development Open Access option.
This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
