Pathways to balance mitochondrial translation and protein import
- 1Institute of Biochemistry and Molecular Biology, Center for Biochemistry and Molecular Cell Research (ZBMZ), Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany;
- 2Faculty of Biology, University of Freiburg, D-79104 Freiburg, Germany;
- 3BIOSS Centre for Biological Signaling Studies, University of Freiburg, D-79104 Freiburg, Germany
- Corresponding author: thomas.becker{at}biochemie.uni-freiburg.de
Abstract
Mitochondria contain their own genome that encodes for a small number of proteins, while the vast majority of mitochondrial proteins is produced on cytosolic ribosomes. The formation of respiratory chain complexes depends on the coordinated biogenesis of mitochondrially encoded and nuclear-encoded subunits. In this review, we describe pathways that adjust mitochondrial protein synthesis and import of nuclear-encoded subunits to the assembly of respiratory chain complexes. Furthermore, we outline how defects in protein import into mitochondria affect nuclear gene expression to maintain protein homeostasis under physiological and stress conditions.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.316547.118.
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