ATAC-king the complexity of SAGA during evolution

Gianpiero Spedale; H.Th. Marc Timmers; W.W.M. Pim Pijnappel

doi:10.1101/gad.184705.111

ATAC-king the complexity of SAGA during evolution

Molecular Cancer Research, Netherlands Proteomics Center, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands

↵1 These authors contributed equally to this work.

↵2 Present addresses: Department of Pediatrics, Center for Lysosomal and Metabolic Diseases, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands;
↵3 Department of Clinical Genetics, Center for Lysosomal and Metabolic Diseases, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

Abstract

The yeast SAGA (Spt–Ada–Gcn5–acetyltransferase) coactivator complex exerts functions in gene expression, including activator interaction, histone acetylation, histone deubiquitination, mRNA export, chromatin recognition, and regulation of the basal transcription machinery. These diverse functions involve distinct modules within this multiprotein complex. It has now become clear that yeast SAGA has diverged during metazoan evolution into two related complexes, SAGA and ATAC, which exist in two flavors in vertebrates. The compositions of metazoan ATAC and SAGA complexes have been characterized, and functional analyses indicate that these complexes have important but distinct roles in transcription, histone modification, signaling pathways, and cell cycle regulation.