ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Gabriel Balmus; Domenic Pilger; Julia Coates; Mukerrem Demir; Matylda Sczaniecka-Clift; Anna Barros; Michael Woods; Beiyuan Fu; Fengtang Yang; Elisabeth Chen; Matthias Ostermaier; Tatjana Stankovic; Hannes Ponstingl; Mareike Herzog; Kosuke Yusa; Francisco Munoz-Martinez; Stephen T Durant; Yaron Galanty; Petra Beli; David J Adams; Allan Bradley; Emmanouil Metzakopian; Josep V Forment; Stephen Philip P Jackson

doi:10.1101/330043

Article Information

doi

https://doi.org/10.1101/330043

History

May 24, 2018.

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

Gabriel Balmus1 (gb318{at}cam.ac.uk) (https://www.gurdon.cam.ac.uk/),
Domenic Pilger1 (d.pilger{at}gurdon.cam.ac.uk) (https://www.gurdon.cam.ac.uk/),
Julia Coates1 (j.coates{at}gurdon.cam.ac.uk),
Mukerrem Demir1 (m.demir{at}gurdon.cam.ac.uk),
Matylda Sczaniecka-Clift1 (m.sczaniecka-clift{at}gurdon.cam.ac.uk),
Anna Barros2 (ab40{at}sanger.ac.uk),
Michael Woods2 (mw2{at}sanger.ac.uk),
Beiyuan Fu2 (bf2{at}sanger.ac.uk),
Fengtang Yang2 (fy1{at}sanger.ac.uk) (http://www.sanger.ac.uk/science/groups/molecular-cytogenetics),
Elisabeth Chen2 (ec12{at}sanger.ac.uk),
Matthias Ostermaier3 (m.ostermaier{at}imb-mainz.de),
Tatjana Stankovic4 (t.stankovic{at}bham.ac.uk),
Hannes Ponstingl5 (hp3{at}sanger.ac.uk),
Mareike Herzog1 (herzmare{at}gmail.com),
Kosuke Yusa2 (ky1{at}sanger.ac.uk),
Francisco Munoz-Martinez1 (f.munozmartinez{at}gurdon.cam.ac.uk),
Stephen T Durant6 (stephen.durant{at}astrazeneca.com),
Yaron Galanty1 (y.galanty{at}gurdon.cam.ac.uk),
Petra Beli3 (p.beli{at}imb-mainz.de) (https://www.imb.de/research/beli),
David J Adams5 (da1{at}sanger.ac.uk),
Allan Bradley5 (abradley{at}sanger.ac.uk),
Emmanouil Metzakopian5 (em11{at}sanger.ac.uk),
Josep V Forment7 (josep.forment{at}astrazeneca.com) (http://www2.gurdon.cam.ac.uk/~jacksonlab/) and
Stephen Philip P Jackson1,8 (spj13{at}cam.ac.uk) (http://www.gurdon.cam.ac.uk/research/jackson)

¹ The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge;
² Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;
³ Institute of Molecular Biology (IMB), 55128 Mainz, Germany;
⁴ Institute of Cancer and Genomic Sciences, University of Birmingham;
⁵ Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.;
⁶ DNA Damage Response Biology, Bioscience Oncology IMED Biotech Unit, AstraZeneca, Cambridge CB4 0WG;
⁷ DNA Damage Response Biology, Bioscience Oncology IMED Biotech Unit, AstraZeneca, Cambridge CB4 0WG,