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Objective Classification of Neocortical Pyramidal Cells

View ORCID ProfileLida Kanari, Srikanth Ramaswamy, Ying Shi, Sebastien Morand, Julie Meystre, Rodrigo Perin, Marwan Abdellah, Yun Wang, Kathryn Hess, Henry Markram
doi: https://doi.org/10.1101/349977
Lida Kanari
1Blue Brain Project, Brain & Mind Institute, EPFL, Geneva, Switzerland
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Srikanth Ramaswamy
1Blue Brain Project, Brain & Mind Institute, EPFL, Geneva, Switzerland
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Ying Shi
1Blue Brain Project, Brain & Mind Institute, EPFL, Geneva, Switzerland
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Sebastien Morand
2Laboratory for Topology and Neuroscience, Brain Mind Institute, EPFL, Lausanne, Switzerland
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Julie Meystre
3Laboratory of Neural Microcircuitry, Brain Mind Institute, EPFL, Lausanne, Switzerland
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Rodrigo Perin
3Laboratory of Neural Microcircuitry, Brain Mind Institute, EPFL, Lausanne, Switzerland
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Marwan Abdellah
1Blue Brain Project, Brain & Mind Institute, EPFL, Geneva, Switzerland
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Yun Wang
4School of Optometry & Ophthalmology, Wenzhou Medical College, Wenzhou, Zhejiang, P.R.China
5Allen Institute for Brain Science, Seattle, WA, USA
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Kathryn Hess
2Laboratory for Topology and Neuroscience, Brain Mind Institute, EPFL, Lausanne, Switzerland
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Henry Markram
1Blue Brain Project, Brain & Mind Institute, EPFL, Geneva, Switzerland
3Laboratory of Neural Microcircuitry, Brain Mind Institute, EPFL, Lausanne, Switzerland
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Abstract

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies. This is because of a lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies: the shapes of somata, dendrites, and axons. Even for neurons that are visually different to non-experts, there is no common ground to consistently distinguish morphological types. We found that objective classification is possible with methods from algebraic topology, and that the dendritic arbor is sufficient for reliable identification of distinct types of PCs. We also provide a solution for the more challenging problem of whether two similar neurons belong to different types or to a continuum of the same type. Using this scheme, we objectively identify seventeen types of PCs in the rat somatosensory cortex. Our topological classification does not require expert input, is stable, and helps settle the long-standing debate on whether cell-types are discrete or continuous morphological variations of each other.

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Posted June 19, 2018.
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Objective Classification of Neocortical Pyramidal Cells
Lida Kanari, Srikanth Ramaswamy, Ying Shi, Sebastien Morand, Julie Meystre, Rodrigo Perin, Marwan Abdellah, Yun Wang, Kathryn Hess, Henry Markram
bioRxiv 349977; doi: https://doi.org/10.1101/349977
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Objective Classification of Neocortical Pyramidal Cells
Lida Kanari, Srikanth Ramaswamy, Ying Shi, Sebastien Morand, Julie Meystre, Rodrigo Perin, Marwan Abdellah, Yun Wang, Kathryn Hess, Henry Markram
bioRxiv 349977; doi: https://doi.org/10.1101/349977

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