Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

Thomas E. Wallach; Vasudha Srivastava; Efren Reyes; Ophir D. Klein; Zev J. Gartner

doi:10.1101/2019.12.23.878207

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Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

Thomas E. Wallach, Vasudha Srivastava, Efren Reyes, Ophir D. Klein, Zev J. Gartner

doi: https://doi.org/10.1101/2019.12.23.878207

Thomas E. Wallach

1Department of Pediatrics, Division of Pediatric Gastroenterology, University of California San Francisco, San Francisco, California, USA

2Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA

3Tetrad graduate program, University of California San Francisco, San Francisco, California, USA

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Vasudha Srivastava

2Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA

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Efren Reyes

2Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA

3Tetrad graduate program, University of California San Francisco, San Francisco, California, USA

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Ophir D. Klein

6Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA

7Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA

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Zev J. Gartner

2Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA

3Tetrad graduate program, University of California San Francisco, San Francisco, California, USA

4Center for Cellular Construction, University of California San Francisco, San Francisco, California, USA

5Chan-Zuckerberg Biohub, San Francisco, California, USA

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For correspondence: Zev.gartner@ucsf.edu

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Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

Thomas E. Wallach, Vasudha Srivastava, Efren Reyes, Ophir D. Klein, Zev J. Gartner

bioRxiv 2019.12.23.878207; doi: https://doi.org/10.1101/2019.12.23.878207

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Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

Thomas E. Wallach, Vasudha Srivastava, Efren Reyes, Ophir D. Klein, Zev J. Gartner

bioRxiv 2019.12.23.878207; doi: https://doi.org/10.1101/2019.12.23.878207

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