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Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure

Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Sarah J. Marx, Andreas G. Wibmer, Ilaria Del Gaudio, Scott D. Butler, Caroline S. Jiang, Roger Vaughan, Heiko Schöder, Annarita Di Lorenzo, Allyn Mark, Paul Cohen
doi: https://doi.org/10.1101/2020.02.08.933754
Tobias Becher
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY
9DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Mannheim, Germany
10First Department of Medicine (Division of Cardiology), University Medical Center Mannheim, Mannheim, Germany
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Srikanth Palanisamy
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY
2Weill Cornell Medicine, New York, NY
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Daniel J. Kramer
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY
2Weill Cornell Medicine, New York, NY
3Weill Cornell/ Rockefeller/ Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY
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Sarah J. Marx
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY
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Andreas G. Wibmer
4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY
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Ilaria Del Gaudio
5Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute and Feil Brain and Mind research Institute, Weill Cornell Medicine, New York, NY
11Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
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Scott D. Butler
6Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY
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Caroline S. Jiang
7Center for Clinical and Translational Science, The Rockefeller University, New York
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Roger Vaughan
2Weill Cornell Medicine, New York, NY
7Center for Clinical and Translational Science, The Rockefeller University, New York
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Heiko Schöder
4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY
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Annarita Di Lorenzo
5Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute and Feil Brain and Mind research Institute, Weill Cornell Medicine, New York, NY
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Allyn Mark
8Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa
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Paul Cohen
1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY
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  • For correspondence: pcohen@rockefeller.edu
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Abstract

White fat stores excess energy, while brown and beige fat dissipate energy as heat1. These thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, though the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is unclear2–4. Here, we categorized 139,224 18F-FDG PET/CT scans from 53,475 patients by presence or absence of BAT and used propensity score matching to assemble a study cohort. Individuals with BAT showed lower prevalences of cardiometabolic diseases. Additionally, BAT independently correlated with lower odds of type II diabetes, coronary artery disease and congestive heart failure. These findings were supported by improved glucose, triglyceride and high-density lipoprotein values. The effects of BAT were more pronounced in overweight and obesity, indicating that BAT can offset the deleterious effects of obesity. Strikingly, we also found lower rates of hypertension among patients with BAT. Studies in a mouse model with genetic ablation of beige fat demonstrated elevated blood pressure due to increased sensitivity to angiotensin II in peripheral resistance arteries. In addition to highlighting a role for BAT in promoting overall cardiometabolic health, this study reveals a new link between thermogenic adipose tissue and blood pressure regulation.

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Posted February 10, 2020.
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Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure
Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Sarah J. Marx, Andreas G. Wibmer, Ilaria Del Gaudio, Scott D. Butler, Caroline S. Jiang, Roger Vaughan, Heiko Schöder, Annarita Di Lorenzo, Allyn Mark, Paul Cohen
bioRxiv 2020.02.08.933754; doi: https://doi.org/10.1101/2020.02.08.933754
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Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure
Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Sarah J. Marx, Andreas G. Wibmer, Ilaria Del Gaudio, Scott D. Butler, Caroline S. Jiang, Roger Vaughan, Heiko Schöder, Annarita Di Lorenzo, Allyn Mark, Paul Cohen
bioRxiv 2020.02.08.933754; doi: https://doi.org/10.1101/2020.02.08.933754

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