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Identity domains in complex behavior: Toward a biology of personality

Oren Forkosh, Stoyo Karamihalev, Simone Roeh, Mareen Engel, Uri Alon, Sergey Anpilov, Markus Nussbaumer, Cornelia Flachskamm, Paul Kaplick, Yair Shemesh, Alon Chen
doi: https://doi.org/10.1101/395111
Oren Forkosh
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Stoyo Karamihalev
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
2Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
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Simone Roeh
3Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Mareen Engel
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Uri Alon
4Department Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
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Sergey Anpilov
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
2Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
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Markus Nussbaumer
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Cornelia Flachskamm
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Paul Kaplick
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
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Yair Shemesh
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
2Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
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Alon Chen
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804, Germany
2Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
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  • For correspondence: chen@psych.mpg.de
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Abstract

Personality traits offer considerable insight into the biological basis of individual differences. However, existing approaches toward understanding personality across species rely on subjective criteria and limited sets of behavioral readouts, resulting in noisy and often inconsistent outcomes. Here, we introduce a mathematical framework for studying individual differences along dimensions with maximum consistency and discriminative power. We validate this framework in mice, using data from a system for high-throughput longitudinal monitoring of group-housed mice that yields a variety of readouts from all across an individual’s behavioral repertoire. We describe a set of stable traits that capture variability in behavior and gene expression in the brain, allowing for better informed mechanistic investigations into the biology of individual differences.

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Posted August 20, 2018.
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Identity domains in complex behavior: Toward a biology of personality
Oren Forkosh, Stoyo Karamihalev, Simone Roeh, Mareen Engel, Uri Alon, Sergey Anpilov, Markus Nussbaumer, Cornelia Flachskamm, Paul Kaplick, Yair Shemesh, Alon Chen
bioRxiv 395111; doi: https://doi.org/10.1101/395111
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Identity domains in complex behavior: Toward a biology of personality
Oren Forkosh, Stoyo Karamihalev, Simone Roeh, Mareen Engel, Uri Alon, Sergey Anpilov, Markus Nussbaumer, Cornelia Flachskamm, Paul Kaplick, Yair Shemesh, Alon Chen
bioRxiv 395111; doi: https://doi.org/10.1101/395111

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