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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Denis Touroutine, Christopher M. Lambert, Lilianne Schoofs, Isabel Beets, View ORCID ProfileMichael M. Francis
doi: https://doi.org/10.1101/2020.04.27.064550
Shankar Ramachandran
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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Navonil Banerjee
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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Raja Bhattacharya
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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Denis Touroutine
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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Christopher M. Lambert
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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Lilianne Schoofs
2Department of Biology, University of Leuven (KU Leuven), Leuven, Belgium
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Isabel Beets
2Department of Biology, University of Leuven (KU Leuven), Leuven, Belgium
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Michael M. Francis
1Department of Neurobiology, 715 Lazare Research Building, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605
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  • ORCID record for Michael M. Francis
  • For correspondence: michael.francis@umassmed.edu
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SUMMARY

Neuromodulators promote adaptive behaviors in response to either environmental or internal physiological changes. These responses are often complex and may involve concerted activity changes across circuits that are not physically connected. It is not well understood how neuromodulatory systems act across circuits to elicit complex behavioral responses. Here we show that the C. elegans NLP-12 neuropeptide system shapes responses to food availability by selectively modulating the activity of head and body wall motor neurons. NLP-12 modulation of the head and body wall motor circuits is generated through conditional involvement of alternate GPCR targets. The CKR-1 GPCR is highly expressed in the head motor circuit, and functions to enhance head bending and increase trajectory reorientations during local food searching, primarily through stimulatory actions on SMD head motor neurons. In contrast, NLP-12 activation of CKR-1 and CKR-2 GPCRs regulates body bending under basal conditions, primarily through actions on body wall motor neurons. Thus, locomotor responses to changing environmental conditions emerge from conditional NLP-12 stimulation of head or body wall motor neuron targets.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 28, 2020.
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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Denis Touroutine, Christopher M. Lambert, Lilianne Schoofs, Isabel Beets, Michael M. Francis
bioRxiv 2020.04.27.064550; doi: https://doi.org/10.1101/2020.04.27.064550
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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Denis Touroutine, Christopher M. Lambert, Lilianne Schoofs, Isabel Beets, Michael M. Francis
bioRxiv 2020.04.27.064550; doi: https://doi.org/10.1101/2020.04.27.064550

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