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The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
View ORCID ProfileShi Chen, View ORCID ProfileRafal P. Wiewiora, View ORCID ProfileFanwang Meng, Nicolas Babault, Anqi Ma, Wenyu Yu, Kun Qian, Hao Hu, Hua Zou, Junyi Wang, Shijie Fan, Gil Blum, View ORCID ProfileFabio Pittella-Silva, View ORCID ProfileKyle A. Beauchamp, Wolfram Tempel, Hualiang Jiang, Kaixian Chen, Robert Skene, View ORCID ProfileY. George Zheng, Peter J. Brown, View ORCID ProfileJian Jin, View ORCID ProfileCheng Luo, View ORCID ProfileJohn D. Chodera, View ORCID ProfileMinkui Luo
doi: https://doi.org/10.1101/438994
Shi Chen
1Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
2Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Rafal P. Wiewiora
1Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
3Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Fanwang Meng
4Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Nicolas Babault
5Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Anqi Ma
5Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Wenyu Yu
6Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada
Kun Qian
7Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, 30602, USA
Hao Hu
7Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, 30602, USA
Hua Zou
8Takeda California, 10410 Science Center Drive, San Diego, CA 92121, USA
Junyi Wang
2Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Shijie Fan
4Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
9University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
Gil Blum
2Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Fabio Pittella-Silva
2Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Kyle A. Beauchamp
3Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Wolfram Tempel
6Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada
Hualiang Jiang
4Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
9University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
Kaixian Chen
4Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
9University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
Robert Skene
8Takeda California, 10410 Science Center Drive, San Diego, CA 92121, USA
Y. George Zheng
7Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, 30602, USA
Peter J. Brown
6Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada
Jian Jin
5Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Cheng Luo
4Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
9University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
John D. Chodera
3Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Minkui Luo
2Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
10Program of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
Article usage
Posted October 12, 2018.
The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
Shi Chen, Rafal P. Wiewiora, Fanwang Meng, Nicolas Babault, Anqi Ma, Wenyu Yu, Kun Qian, Hao Hu, Hua Zou, Junyi Wang, Shijie Fan, Gil Blum, Fabio Pittella-Silva, Kyle A. Beauchamp, Wolfram Tempel, Hualiang Jiang, Kaixian Chen, Robert Skene, Y. George Zheng, Peter J. Brown, Jian Jin, Cheng Luo, John D. Chodera, Minkui Luo
bioRxiv 438994; doi: https://doi.org/10.1101/438994
The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
Shi Chen, Rafal P. Wiewiora, Fanwang Meng, Nicolas Babault, Anqi Ma, Wenyu Yu, Kun Qian, Hao Hu, Hua Zou, Junyi Wang, Shijie Fan, Gil Blum, Fabio Pittella-Silva, Kyle A. Beauchamp, Wolfram Tempel, Hualiang Jiang, Kaixian Chen, Robert Skene, Y. George Zheng, Peter J. Brown, Jian Jin, Cheng Luo, John D. Chodera, Minkui Luo
bioRxiv 438994; doi: https://doi.org/10.1101/438994
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