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Population dynamics of underdominance gene drive systems in continuous space

View ORCID ProfileJackson Champer, Joanna Zhao, Joanna Zhao, Samuel E. Champer, View ORCID ProfileJingxian Liu, View ORCID ProfilePhilipp W. Messer
doi: https://doi.org/10.1101/449355
Jackson Champer
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
2Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853
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  • For correspondence: jc3248@cornell.edu messer@cornell.edu
Joanna Zhao
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
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Joanna Zhao
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
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Samuel E. Champer
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
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Jingxian Liu
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
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Philipp W. Messer
1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853
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  • For correspondence: jc3248@cornell.edu messer@cornell.edu
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ABSTRACT

Underdominance gene drive systems promise a mechanism for rapidly spreading payload alleles through a local population while otherwise remaining confined, unable to spread into neighboring populations due to their frequency-dependent dynamics. Such systems could provide a new tool in the fight against vector-borne diseases by disseminating transgenic payloads through vector populations. If local confinement can indeed be achieved, the decision-making process for the release of such constructs would likely be considerably simpler compared to other gene drive mechanisms such as CRISPR homing drives. So far, the confinement ability of underdominance systems has only been demonstrated in models of panmictic populations linked by migration. How such systems would behave in realistic populations where individuals move over continuous space remains largely unknown. Here, we study several underdominance systems in continuous-space population models and show that their dynamics are drastically altered from those in panmictic populations. Specifically, we find that all underdominance systems we studied can fail to persist in such environments, even after successful local establishment. At the same time, we find that a two-locus two-toxin-antitoxin system can still successfully invade neighboring populations in many scenarios even under weak migration. This suggests that the parameter space for underdominance systems to both establish in a given region and remain confined to that region would likely be highly limited. Overall, these results indicate that spatial context must be considered when assessing strategies for the deployment of underdominance systems.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 22, 2018.
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Population dynamics of underdominance gene drive systems in continuous space
Jackson Champer, Joanna Zhao, Joanna Zhao, Samuel E. Champer, Jingxian Liu, Philipp W. Messer
bioRxiv 449355; doi: https://doi.org/10.1101/449355
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Population dynamics of underdominance gene drive systems in continuous space
Jackson Champer, Joanna Zhao, Joanna Zhao, Samuel E. Champer, Jingxian Liu, Philipp W. Messer
bioRxiv 449355; doi: https://doi.org/10.1101/449355

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