Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genes

Benjamin D. Hobson; Se Joon Choi; Rajesh K. Soni; David Sulzer; Peter A. Sims

doi:10.1101/2021.06.01.446584

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Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genes

Benjamin D. Hobson, Se Joon Choi, Rajesh K. Soni, David Sulzer, Peter A. Sims

doi: https://doi.org/10.1101/2021.06.01.446584

Benjamin D. Hobson

1Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032

2Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032

4Department of Psychiatry, Columbia University Irving Medical Center, New York, NY 10032

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Se Joon Choi

6Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032

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Rajesh K. Soni

7Proteomics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032

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David Sulzer

3Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032

4Department of Psychiatry, Columbia University Irving Medical Center, New York, NY 10032

5Department of Pharmacology, Columbia University Irving Medical Center, New York, NY 10032

6Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032

10Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD

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For correspondence: pas2182@cumc.columbia.edu ds43@cumc.columbia.edu

Peter A. Sims

1Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032

8Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032

9Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, NY 10032

10Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD

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For correspondence: pas2182@cumc.columbia.edu ds43@cumc.columbia.edu

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Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genes

Benjamin D. Hobson, Se Joon Choi, Rajesh K. Soni, David Sulzer, Peter A. Sims

bioRxiv 2021.06.01.446584; doi: https://doi.org/10.1101/2021.06.01.446584

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Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genes

Benjamin D. Hobson, Se Joon Choi, Rajesh K. Soni, David Sulzer, Peter A. Sims

bioRxiv 2021.06.01.446584; doi: https://doi.org/10.1101/2021.06.01.446584

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