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Local genetic effects on gene expression across 44 human tissues
François Aguet, Andrew A. Brown, Stephane E. Castel, Joe R. Davis, Pejman Mohammadi, Ayellet V. Segrè, Zachary Zappala, Nathan S. Abell, Laure Frésard, Eric R. Gamazon, Ellen Gelfand, Michael J. Gloudemans, Yuan He, Farhad Hormozdiari, Xiao Li, Xin Li, Boxiang Liu, Diego Garrido-Martín, Halit Ongen, John J. Palowitch, YoSon Park, Christine B. Peterson, Gerald Quon, Stephan Ripke, Andrey A. Shabalin, Tyler C. Shimko, Benjamin J. Strober, Timothy J. Sullivan, Nicole A. Teran, Emily K. Tsang, Hailei Zhang, Yi-Hui Zhou, Alexis Battle, Carlos D. Bustamonte, Nancy J. Cox, Barbara E. Engelhardt, Eleazar Eskin, Gad Getz, Manolis Kellis, Gen Li, Daniel G. MacArthur, Andrew B. Nobel, Chiara Sabbati, Xiaoquan Wen, Fred A. Wright, GTEx Consortium, Tuuli Lappalainen, Kristin G. Ardlie, Emmanouil T. Dermitzakis, View ORCID ProfileChristopher D. Brown, Stephen B. Montgomery
doi: https://doi.org/10.1101/074450
François Aguet
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Andrew A. Brown
2Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
3Institute for Genetics and Genomics in Geneva (iG3), University of Geneva, 1211 Geneva, Switzerland
4Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Stephane E. Castel
5New York Genome Center, New York, NY, 10013, USA
6Department of Systems Biology, Columbia University, New York, NY, 10032, USA
Joe R. Davis
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Pejman Mohammadi
5New York Genome Center, New York, NY, 10013, USA
6Department of Systems Biology, Columbia University, New York, NY, 10032, USA
Ayellet V. Segrè
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Zachary Zappala
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Nathan S. Abell
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Laure Frésard
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Eric R. Gamazon
9Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, 37232, USA
Ellen Gelfand
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Michael J. Gloudemans
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
10Biomedical Informatics Program, Stanford University, Stanford, CA, 94305, USA
Yuan He
11Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA
Farhad Hormozdiari
12Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA
Xiao Li
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Xin Li
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Boxiang Liu
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
13Department of Biology, Stanford University, Stanford, CA, 94305, USA
Diego Garrido-Martín
14Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
15Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
Halit Ongen
2Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
3Institute for Genetics and Genomics in Geneva (iG3), University of Geneva, 1211 Geneva, Switzerland
4Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
John J. Palowitch
16Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC, 27599, USA
YoSon Park
17Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA
Christine B. Peterson
18Department of Biomedical Data Science, Stanford University, Stanford, CA, 94305, USA
19Present address: Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA
Gerald Quon
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
20Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, 02139, USA
Stephan Ripke
21Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
22Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA
Andrey A. Shabalin
23Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
Tyler C. Shimko
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Benjamin J. Strober
11Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA
Timothy J. Sullivan
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Nicole A. Teran
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Emily K. Tsang
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Hailei Zhang
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Yi-Hui Zhou
24Bioinformatics Research Center and Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695, USA
Alexis Battle
25Department of Computer Science, Johns Hopkins University, Baltimore, MD, 21218, USA
Carlos D. Bustamonte
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
26Department of Statistics, Stanford University, Stanford, CA, 94305, USA
Nancy J. Cox
9Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, 37232, USA
Barbara E. Engelhardt
27Department of Computer Science, Center for Statistics and Machine Learning, Princeton University, Princeton, NJ, 08540, USA
Eleazar Eskin
12Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA
28Department of Computer Science, University of California, Los Angeles, CA, 90095, USA
Gad Getz
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
29Massachusetts General Hospital Cancer Center and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
Manolis Kellis
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
20Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, 02139, USA
Gen Li
30Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
Daniel G. MacArthur
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
20Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, 02139, USA
Andrew B. Nobel
16Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC, 27599, USA
Chiara Sabbati
18Department of Biomedical Data Science, Stanford University, Stanford, CA, 94305, USA
26Department of Statistics, Stanford University, Stanford, CA, 94305, USA
Xiaoquan Wen
31Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA
Fred A. Wright
24Bioinformatics Research Center and Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695, USA
32Department of Statistics, North Carolina State University, Raleigh NC, 27695, USA
Tuuli Lappalainen
5New York Genome Center, New York, NY, 10013, USA
6Department of Systems Biology, Columbia University, New York, NY, 10032, USA
Kristin G. Ardlie
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA
Emmanouil T. Dermitzakis
2Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
3Institute for Genetics and Genomics in Geneva (iG3), University of Geneva, 1211 Geneva, Switzerland
4Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Christopher D. Brown
17Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA
Stephen B. Montgomery
7Department of Genetics, Stanford University, Stanford, CA, 94305, USA
8Department of Pathology, Stanford University, Stanford, CA, 94305, USA
Article usage
Posted September 09, 2016.
Local genetic effects on gene expression across 44 human tissues
François Aguet, Andrew A. Brown, Stephane E. Castel, Joe R. Davis, Pejman Mohammadi, Ayellet V. Segrè, Zachary Zappala, Nathan S. Abell, Laure Frésard, Eric R. Gamazon, Ellen Gelfand, Michael J. Gloudemans, Yuan He, Farhad Hormozdiari, Xiao Li, Xin Li, Boxiang Liu, Diego Garrido-Martín, Halit Ongen, John J. Palowitch, YoSon Park, Christine B. Peterson, Gerald Quon, Stephan Ripke, Andrey A. Shabalin, Tyler C. Shimko, Benjamin J. Strober, Timothy J. Sullivan, Nicole A. Teran, Emily K. Tsang, Hailei Zhang, Yi-Hui Zhou, Alexis Battle, Carlos D. Bustamonte, Nancy J. Cox, Barbara E. Engelhardt, Eleazar Eskin, Gad Getz, Manolis Kellis, Gen Li, Daniel G. MacArthur, Andrew B. Nobel, Chiara Sabbati, Xiaoquan Wen, Fred A. Wright, GTEx Consortium, Tuuli Lappalainen, Kristin G. Ardlie, Emmanouil T. Dermitzakis, Christopher D. Brown, Stephen B. Montgomery
bioRxiv 074450; doi: https://doi.org/10.1101/074450
Local genetic effects on gene expression across 44 human tissues
François Aguet, Andrew A. Brown, Stephane E. Castel, Joe R. Davis, Pejman Mohammadi, Ayellet V. Segrè, Zachary Zappala, Nathan S. Abell, Laure Frésard, Eric R. Gamazon, Ellen Gelfand, Michael J. Gloudemans, Yuan He, Farhad Hormozdiari, Xiao Li, Xin Li, Boxiang Liu, Diego Garrido-Martín, Halit Ongen, John J. Palowitch, YoSon Park, Christine B. Peterson, Gerald Quon, Stephan Ripke, Andrey A. Shabalin, Tyler C. Shimko, Benjamin J. Strober, Timothy J. Sullivan, Nicole A. Teran, Emily K. Tsang, Hailei Zhang, Yi-Hui Zhou, Alexis Battle, Carlos D. Bustamonte, Nancy J. Cox, Barbara E. Engelhardt, Eleazar Eskin, Gad Getz, Manolis Kellis, Gen Li, Daniel G. MacArthur, Andrew B. Nobel, Chiara Sabbati, Xiaoquan Wen, Fred A. Wright, GTEx Consortium, Tuuli Lappalainen, Kristin G. Ardlie, Emmanouil T. Dermitzakis, Christopher D. Brown, Stephen B. Montgomery
bioRxiv 074450; doi: https://doi.org/10.1101/074450
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