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Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure: implications for variant effect prediction
Lukas Gerasimavicius, Benjamin J Livesey, View ORCID ProfileJoseph A. Marsh
doi: https://doi.org/10.1101/2021.10.23.465554
Lukas Gerasimavicius
MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK
Benjamin J Livesey
MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK
Joseph A. Marsh
MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK
Posted October 24, 2021.
Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure: implications for variant effect prediction
Lukas Gerasimavicius, Benjamin J Livesey, Joseph A. Marsh
bioRxiv 2021.10.23.465554; doi: https://doi.org/10.1101/2021.10.23.465554
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