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Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis

View ORCID ProfileMaría Cristina Ortega, Rafael Lebrón-Galán, Isabel Machín-Díaz, Michelle Naughton, Inmaculada Pérez-Molina, Jennifer García-Arocha, Jose Manuel García-Domínguez, Haydee Goicoechea-Briceño, Virginia Vila-del Sol, Víctor Quintanero-Casero, Rosa García-Montero, Victoria Galán, Celia Camacho-Toledano, María Luisa Martínez-Ginés, Denise C. Fitzgerald, View ORCID ProfileDiego Clemente
doi: https://doi.org/10.1101/2022.04.20.488896
María Cristina Ortega
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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  • ORCID record for María Cristina Ortega
Rafael Lebrón-Galán
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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Isabel Machín-Díaz
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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Michelle Naughton
2Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, 97 Lisburn Rd, BT9 7BL. Belfast (Northern Ireland, UK)
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Inmaculada Pérez-Molina
3Departamento de Neurología, Hospital Universitario Virgen de la Salud. Av. De Barber 30, 45004, Toledo (Spain)
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Jennifer García-Arocha
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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Jose Manuel García-Domínguez
4Departamento de Neurología, Hospital General Universitario Gregorio Marañón. Calle del Dr. Esquerdo 46, 28007, Madrid (Spain)
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Haydee Goicoechea-Briceño
4Departamento de Neurología, Hospital General Universitario Gregorio Marañón. Calle del Dr. Esquerdo 46, 28007, Madrid (Spain)
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Virginia Vila-del Sol
5Servicio de Citometría de Flujo, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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Víctor Quintanero-Casero
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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Rosa García-Montero
3Departamento de Neurología, Hospital Universitario Virgen de la Salud. Av. De Barber 30, 45004, Toledo (Spain)
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Victoria Galán
3Departamento de Neurología, Hospital Universitario Virgen de la Salud. Av. De Barber 30, 45004, Toledo (Spain)
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Celia Camacho-Toledano
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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María Luisa Martínez-Ginés
4Departamento de Neurología, Hospital General Universitario Gregorio Marañón. Calle del Dr. Esquerdo 46, 28007, Madrid (Spain)
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Denise C. Fitzgerald
2Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, 97 Lisburn Rd, BT9 7BL. Belfast (Northern Ireland, UK)
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Diego Clemente
1Grupo de Neuroinmuno-Reparación, Hospital Nacional de Parapléjicos, SESCAM. Finca “La Peraleda” s/n, 45071, Toledo (Spain)
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  • ORCID record for Diego Clemente
  • For correspondence: dclemente@sescam.jccm.es
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ABSTRACT

Multiple Sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to foresee disease severity. Previous retrospective investigations in the MS model, experimental autoimmune encephalomyelitis (EAE), highlighted the important relationship between monocytic-myeloid-derived suppressor cells (M-MDSCs) and the experimented severity of the clinical course. In this work, we show for the first time cells resembling M-MDSCs associated to MS lesions, whose abundance was related to milder MS clinical courses. Moreover, Ly-6Chi cells (which are indistinguishable from circulating M-MDSCs in mice) are useful biomarkers to predict a milder severity of the EAE disease course and a lesser tissue damage extent. Finally, the abundance of M-MDSCs in blood from untreated MS patients at their first relapse was inversely correlated with EDSS at baseline and relapse recovery one-year later. In summary, our data point to M-MDSC load as a promising biomarker of patient’s clinical course severity.

Teaser The abundance of myeloid-derived suppressor cells is related to a milder clinical course in multiple sclerosis patients.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 20, 2022.
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Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis
María Cristina Ortega, Rafael Lebrón-Galán, Isabel Machín-Díaz, Michelle Naughton, Inmaculada Pérez-Molina, Jennifer García-Arocha, Jose Manuel García-Domínguez, Haydee Goicoechea-Briceño, Virginia Vila-del Sol, Víctor Quintanero-Casero, Rosa García-Montero, Victoria Galán, Celia Camacho-Toledano, María Luisa Martínez-Ginés, Denise C. Fitzgerald, Diego Clemente
bioRxiv 2022.04.20.488896; doi: https://doi.org/10.1101/2022.04.20.488896
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Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis
María Cristina Ortega, Rafael Lebrón-Galán, Isabel Machín-Díaz, Michelle Naughton, Inmaculada Pérez-Molina, Jennifer García-Arocha, Jose Manuel García-Domínguez, Haydee Goicoechea-Briceño, Virginia Vila-del Sol, Víctor Quintanero-Casero, Rosa García-Montero, Victoria Galán, Celia Camacho-Toledano, María Luisa Martínez-Ginés, Denise C. Fitzgerald, Diego Clemente
bioRxiv 2022.04.20.488896; doi: https://doi.org/10.1101/2022.04.20.488896

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