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Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging

View ORCID ProfileMichael S. Haney, View ORCID ProfileArchana Shankar, Ian Hsu, Masashi Miyauchi, View ORCID ProfileRóbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, View ORCID ProfileTony Wyss-Coray, Hiromitsu Nakauchi, View ORCID ProfileAdam C. Wilkinson
doi: https://doi.org/10.1101/2022.07.22.501030
Michael S. Haney
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
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  • ORCID record for Michael S. Haney
Archana Shankar
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
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  • ORCID record for Archana Shankar
Ian Hsu
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
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Masashi Miyauchi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
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Róbert Pálovics
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
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  • ORCID record for Róbert Pálovics
Hwei Minn Khoo
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
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Kyomi J. Igarashi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
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Joydeep Bhadury
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
6Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg; Gothenburg, Sweden
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Christy Munson
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
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Paul K. Mack
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
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Tze-Kai Tan
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
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Tony Wyss-Coray
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
7ChEM-H, Stanford University; Stanford, CA, USA
8Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine; Stanford, CA, USA
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  • ORCID record for Tony Wyss-Coray
  • For correspondence: adam.wilkinson@imm.ox.ac.uk nakauchi@stanford.edu twc@stanford.edu
Hiromitsu Nakauchi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
9Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo; Tokyo, Japan
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  • For correspondence: adam.wilkinson@imm.ox.ac.uk nakauchi@stanford.edu twc@stanford.edu
Adam C. Wilkinson
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
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  • ORCID record for Adam C. Wilkinson
  • For correspondence: adam.wilkinson@imm.ox.ac.uk nakauchi@stanford.edu twc@stanford.edu
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Posted July 22, 2022.
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Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
Michael S. Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C. Wilkinson
bioRxiv 2022.07.22.501030; doi: https://doi.org/10.1101/2022.07.22.501030
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Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
Michael S. Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C. Wilkinson
bioRxiv 2022.07.22.501030; doi: https://doi.org/10.1101/2022.07.22.501030

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