Death by a Thousand Cuts – Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

Ian R. Outhwaite; Sukrit Singh; Benedict-Tilman Berger; Stefan Knapp; John D. Chodera; Markus A. Seeliger

doi:10.1101/2023.01.13.523972

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Death by a Thousand Cuts – Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

View ORCID ProfileIan R. Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, View ORCID ProfileJohn D. Chodera, Markus A. Seeliger

doi: https://doi.org/10.1101/2023.01.13.523972

Ian R. Outhwaite

1Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794

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ORCID record for Ian R. Outhwaite

Sukrit Singh

1Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794

2Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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Benedict-Tilman Berger

3Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany

4Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany

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Stefan Knapp

3Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany

4Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany

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John D. Chodera

2Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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ORCID record for John D. Chodera

Markus A. Seeliger

1Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794

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For correspondence: markus.seeliger@stonybrook.edu

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Posted January 16, 2023.

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Death by a Thousand Cuts – Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

Ian R. Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D. Chodera, Markus A. Seeliger

bioRxiv 2023.01.13.523972; doi: https://doi.org/10.1101/2023.01.13.523972

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Death by a Thousand Cuts – Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

Ian R. Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D. Chodera, Markus A. Seeliger

bioRxiv 2023.01.13.523972; doi: https://doi.org/10.1101/2023.01.13.523972

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