Notch induces transcription by stimulating release of paused RNA Polymerase II

Julia M Rogers; Claudia A Mimoso; Benjamin JE Martin; Alexandre P Martin; Jon C Aster; Karen Adelman; Stephen C Blacklow

doi:10.1101/2024.06.13.598853

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Notch induces transcription by stimulating release of paused RNA Polymerase II

View ORCID ProfileJulia M Rogers, Claudia A Mimoso, View ORCID ProfileBenjamin JE Martin, Alexandre P Martin, Jon C Aster, Karen Adelman, Stephen C Blacklow

doi: https://doi.org/10.1101/2024.06.13.598853

Julia M Rogers

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Claudia A Mimoso

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Benjamin JE Martin

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Alexandre P Martin

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Jon C Aster

2Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02215, USA

3Ludwig Center at Harvard, Boston, MA 02115, USA

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Karen Adelman

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

3Ludwig Center at Harvard, Boston, MA 02115, USA

4The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA

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For correspondence: karen_adelman@hms.harvard.edu stephen_blacklow@hms.harvard.edu

Stephen C Blacklow

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

4The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA

5Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA

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For correspondence: karen_adelman@hms.harvard.edu stephen_blacklow@hms.harvard.edu