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The complete connectome of a learning and memory center in an insect brain

Katharina Eichler, View ORCID ProfileFeng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, View ORCID ProfileCasey M. Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, View ORCID ProfileBertram Gerber, Richard D. Fetter, James W. Truman, Carey E. Priebe, L. F. Abbott, Andreas S. Thum, Marta Zlatic, View ORCID ProfileAlbert Cardona
doi: https://doi.org/10.1101/141762
Katharina Eichler
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
2Department of Biology, University of Konstanz, 78464 Konstanz, Germany
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Feng Li
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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Ashok Litwin-Kumar
3Department of Neuroscience, Columbia University
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Youngser Park
4Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University
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Ingrid Andrade
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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Casey M. Schneider-Mizell
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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Timo Saumweber
5Abteilung Genetik von Lernen und Gedächtnis, Leibniz Institut für Neurobiologie (LIN), 39118 Magdeburg, Germany
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Annina Huser
2Department of Biology, University of Konstanz, 78464 Konstanz, Germany
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Claire Eschbach
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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Bertram Gerber
5Abteilung Genetik von Lernen und Gedächtnis, Leibniz Institut für Neurobiologie (LIN), 39118 Magdeburg, Germany
6Otto von Guericke Universität Magdeburg, Institut für Biologie, Verhaltensgenetik, Universitätsplatz 2, 39106 Magdeburg, Germany
7Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany
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Richard D. Fetter
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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James W. Truman
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
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Carey E. Priebe
4Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University
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L. F. Abbott
3Department of Neuroscience, Columbia University
8Department of Physiology and Cellular Biophysics, Columbia University
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Andreas S. Thum
2Department of Biology, University of Konstanz, 78464 Konstanz, Germany
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Marta Zlatic
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
9Department of Zoology, University of Cambridge
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Albert Cardona
1HHMI Janelia Research Campus, 19700 Helix Dr., Ashburn, VA 20147
10Department of Physiology, Development and Neuroscience, University of Cambridge
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Abstract

Associating stimuli with positive or negative reinforcement is essential for survival, but a complete wiring diagram of a higherorder circuit supporting associative memory has not been previously available. We reconstructed one such circuit at synaptic resolution, the Drosophila larval mushroom body, and found that most Kenyon cells integrate random combinations of inputs but a subset receives stereotyped inputs from single projection neurons. This organization maximizes performance of a model output neuron on a stimulus discrimination task. We also report a novel canonical circuit in each mushroom body compartment with previously unidentified connections: reciprocal Kenyon cell to modulatory neuron connections, modulatory neuron to output neuron connections, and a surprisingly high number of recurrent connections between Kenyon cells. Stereotyped connections between output neurons could enhance the selection of learned responses. The complete circuit map of the mushroom body should guide future functional studies of this learning and memory center.

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Posted May 24, 2017.
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The complete connectome of a learning and memory center in an insect brain
Katharina Eichler, Feng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, Casey M. Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, Bertram Gerber, Richard D. Fetter, James W. Truman, Carey E. Priebe, L. F. Abbott, Andreas S. Thum, Marta Zlatic, Albert Cardona
bioRxiv 141762; doi: https://doi.org/10.1101/141762
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The complete connectome of a learning and memory center in an insect brain
Katharina Eichler, Feng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, Casey M. Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, Bertram Gerber, Richard D. Fetter, James W. Truman, Carey E. Priebe, L. F. Abbott, Andreas S. Thum, Marta Zlatic, Albert Cardona
bioRxiv 141762; doi: https://doi.org/10.1101/141762

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