Transferring functional chromosomes between intergeneric yeast generates monochromosomal hybrids with improved phenotypes and transcriptional responses

Yilin Lyu; Kunfeng Song; Jungang Zhou; Hao Chen; Xueying C. Li; Yao Yu; Hong Lu

doi:10.1101/2025.01.24.634819

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Transferring functional chromosomes between intergeneric yeast generates monochromosomal hybrids with improved phenotypes and transcriptional responses

Yilin Lyu, Kunfeng Song, Jungang Zhou, Hao Chen, View ORCID ProfileXueying C. Li, Yao Yu, Hong Lu

doi: https://doi.org/10.1101/2025.01.24.634819

Yilin Lyu

1School of Life Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

2Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

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Kunfeng Song

1School of Life Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

2Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

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Jungang Zhou

1School of Life Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

2Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

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Hao Chen

3Personal Oncology Inc., Nanjing, Jiangsu Province, China

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Xueying C. Li

4Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University, Beijing, China

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ORCID record for Xueying C. Li
For correspondence: [email protected] [email protected]

Yao Yu

1School of Life Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

2Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

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For correspondence: [email protected] [email protected]

Hong Lu

1School of Life Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

2Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

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https://dataview.ncbi.nlm.nih.gov/object/PRJNA1102743?reviewer=98okerqm686mrj3ddq79r4l18u

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Posted January 25, 2025.

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Transferring functional chromosomes between intergeneric yeast generates monochromosomal hybrids with improved phenotypes and transcriptional responses

Yilin Lyu, Kunfeng Song, Jungang Zhou, Hao Chen, Xueying C. Li, Yao Yu, Hong Lu

bioRxiv 2025.01.24.634819; doi: https://doi.org/10.1101/2025.01.24.634819

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Transferring functional chromosomes between intergeneric yeast generates monochromosomal hybrids with improved phenotypes and transcriptional responses

Yilin Lyu, Kunfeng Song, Jungang Zhou, Hao Chen, Xueying C. Li, Yao Yu, Hong Lu

bioRxiv 2025.01.24.634819; doi: https://doi.org/10.1101/2025.01.24.634819

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