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MDMA impairs response to water intake in healthy volunteers

View ORCID ProfileMatthew J. Baggott, View ORCID ProfileKathleen J. Garrison, View ORCID ProfileJeremy R. Coyle, View ORCID ProfileGantt P. Galloway, View ORCID ProfileAllan J. Barnes, View ORCID ProfileMarilyn A. Huestis, View ORCID ProfileJohn E. Mendelson
doi: https://doi.org/10.1101/021113
Matthew J. Baggott
1San Francisco, California
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Kathleen J. Garrison
2Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, California
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Jeremy R. Coyle
3Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, California
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Gantt P. Galloway
2Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, California
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Allan J. Barnes
4Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, NIH
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Marilyn A. Huestis
4Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, NIH
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John E. Mendelson
2Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, California
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  • ORCID record for John E. Mendelson
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Abstract

Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum sodium, but did not increase ADH or copeptin, although the control prazosin did increase ADH. Water loading reduced serum sodium more after MDMA than after placebo. There was a trend for women to have lower baseline serum sodium than men, but there were no significant interactions with drug condition. Combining studies, MDMA potentiated the ability of water to lower serum sodium. Thus, while MDMA lowers serum sodium and potentiates effects of water intake on serum sodium, ADH may not be the mechanism of these changes.

Footnotes

  • Contact Information: matthew{at}baggott.net, phone (650) 716-4753

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 18, 2015.
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MDMA impairs response to water intake in healthy volunteers
Matthew J. Baggott, Kathleen J. Garrison, Jeremy R. Coyle, Gantt P. Galloway, Allan J. Barnes, Marilyn A. Huestis, John E. Mendelson
bioRxiv 021113; doi: https://doi.org/10.1101/021113
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MDMA impairs response to water intake in healthy volunteers
Matthew J. Baggott, Kathleen J. Garrison, Jeremy R. Coyle, Gantt P. Galloway, Allan J. Barnes, Marilyn A. Huestis, John E. Mendelson
bioRxiv 021113; doi: https://doi.org/10.1101/021113

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