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GPRIN1 modulates neuronal signal transduction and affects mouse-learning behavior

View ORCID ProfileEl Hadji Mamadou Dioum, Claudia Savoia, Julien Benjamin Pujol, Angélique Vaucher, Umberto De Marchi, Claus Rieker, Eija Heikkilä, Antonio Nunez Galindo, Loïc Dayon
doi: https://doi.org/10.1101/291377
El Hadji Mamadou Dioum
Nestle Institute of Health Sciences
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  • For correspondence: elhadjimamadou.dioum@rd.nestle.com
Claudia Savoia
Nestle Institute of Health Sciences
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Julien Benjamin Pujol
Nestle Institute of Health Sciences
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Angélique Vaucher
Nestle Institute of Health Sciences
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Umberto De Marchi
Nestle Institute of Health Sciences
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Claus Rieker
Nestle Institute of Health Sciences
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Eija Heikkilä
Nestle Institute of Health Sciences
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Antonio Nunez Galindo
Nestle Institute of Health Sciences
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Loïc Dayon
Nestle Institute of Health Sciences
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Abstract

In the adult and developing brain, G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) is a downstream effector for Gαo/i/z proteins that promotes neurite outgrowth. However, so far, the physiological role of GPRIN1 in brain health has not been reported. We generated a viable GPRIN1 whole-body knockout mouse to assess its physiological role in synaptic function both ex vivo and in vivo. In adult neurons, GPRIN1 is highly localized to the plasma membrane and synapses where it regulates neuronal signal transduction and Ca2+ homeostasis. Our results reveal that GPRIN1 might be a novel protein involved in agonist-stimulated cytoskeletal reorganization, which is crucial for early neuronal network development and in functionally mature neurons. Finally, we show that loss of GPRIN1 leads to a learning deficit in vivo and sensitizes neurons to stress, suggesting a modulatory role in brain health and disease.

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Posted March 30, 2018.
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GPRIN1 modulates neuronal signal transduction and affects mouse-learning behavior
El Hadji Mamadou Dioum, Claudia Savoia, Julien Benjamin Pujol, Angélique Vaucher, Umberto De Marchi, Claus Rieker, Eija Heikkilä, Antonio Nunez Galindo, Loïc Dayon
bioRxiv 291377; doi: https://doi.org/10.1101/291377
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GPRIN1 modulates neuronal signal transduction and affects mouse-learning behavior
El Hadji Mamadou Dioum, Claudia Savoia, Julien Benjamin Pujol, Angélique Vaucher, Umberto De Marchi, Claus Rieker, Eija Heikkilä, Antonio Nunez Galindo, Loïc Dayon
bioRxiv 291377; doi: https://doi.org/10.1101/291377

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