[HTML][HTML] Integrated intracellular organization and its variations in human iPS cells
…, CL Frick, G Fujioka, MA Fuqua, JL Gehring, KA Gerbin… - Nature, 2023 - nature.com
Understanding how a subset of expressed genes dictates cellular phenotype is a considerable
challenge owing to the large numbers of molecules involved, their combinatorics and the …
challenge owing to the large numbers of molecules involved, their combinatorics and the …
[PDF][PDF] Cell states beyond transcriptomics: Integrating structural organization and gene expression in hiPSC-derived cardiomyocytes
KA Gerbin, T Grancharova, RM Donovan-Maiye… - Cell Systems, 2021 - cell.com
Although some cell types may be defined anatomically or by physiological function, a
rigorous definition of cell state remains elusive. Here, we develop a quantitative, imaging-based …
rigorous definition of cell state remains elusive. Here, we develop a quantitative, imaging-based …
[HTML][HTML] Enhanced electrical integration of engineered human myocardium via intramyocardial versus epicardial delivery in infarcted rat hearts
Cardiac tissue engineering is a promising approach to provide large-scale tissues for
transplantation to regenerate the heart after ischemic injury, however, integration with the host …
transplantation to regenerate the heart after ischemic injury, however, integration with the host …
[HTML][HTML] The winding road to regenerating the human heart
KA Gerbin, CE Murry - Cardiovascular Pathology, 2015 - Elsevier
Regenerating the human heart is a challenge that has engaged researchers and clinicians
around the globe for nearly a century. From the repair of the first septal defect in 1953, …
around the globe for nearly a century. From the repair of the first septal defect in 1953, …
[PDF][PDF] Fluorescent gene tagging of transcriptionally silent genes in hiPSCs
B Roberts, MC Hendershott, J Arakaki, KA Gerbin… - Stem Cell Reports, 2019 - cell.com
We describe a multistep method for endogenous tagging of transcriptionally silent genes in
human induced pluripotent stem cells (hiPSCs). A monomeric EGFP (mEGFP) fusion tag and …
human induced pluripotent stem cells (hiPSCs). A monomeric EGFP (mEGFP) fusion tag and …
[HTML][HTML] A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes
T Grancharova, KA Gerbin, AB Rosenberg, CM Roco… - Scientific Reports, 2021 - nature.com
We performed a comprehensive analysis of the transcriptional changes occurring during
human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell …
human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell …
Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable
…, CL Frick, G Fujioka, MA Fuqua, JL Gehring, KA Gerbin… - BioRxiv, 2020 - biorxiv.org
Despite the intimate link between cell organization and function, the principles underlying
intracellular organization and the relation between organization, gene expression and …
intracellular organization and the relation between organization, gene expression and …
[HTML][HTML] Delta-1 functionalized hydrogel promotes hESC-cardiomyocyte graft proliferation and maintains heart function post-injury
KA Gerbin, KA Mitzelfelt, X Guan, AM Martinson… - … Therapy Methods & …, 2020 - cell.com
Current cell transplantation techniques are hindered by small graft size, requiring high cell
doses to achieve therapeutic cardiac remuscularization. Enhancing the proliferation of …
doses to achieve therapeutic cardiac remuscularization. Enhancing the proliferation of …
Tissue Engineering Strategies to Improve Post-MI Engraftment of hESC-Derived Cardiomyocytes
KA Gerbin - 2016 - digital.lib.washington.edu
Transplantation of stem cell-derived cardiomyocytes is a promising strategy for repairing
damaged cardiac muscle following a myocardial infarction. Our group and others have …
damaged cardiac muscle following a myocardial infarction. Our group and others have …
Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells
B Roberts, J Arakaki, KA Gerbin, H Malik, A Nelson… - bioRxiv, 2018 - biorxiv.org
We describe a multi-step CRISPR/Cas9 gene editing method to create endogenously tagged
GFP-fusions of transcriptionally silent genes in human induced pluripotent stem cells (…
GFP-fusions of transcriptionally silent genes in human induced pluripotent stem cells (…