Abstract
A five-anchor model is provided to describe the physical working procedure of an individual ion channel. It provide the first principle for ion channel behavior: which is the polarity change of each anchor is induced by electron transition independently. Thus, the long off kenetics of neural stimulation by optogenetics, the stochastic gating pattern of single ion channel under DC voltage, the refractory period of action potential and the nerve conductance block, which are well observed for years in many studies, can [17], be directly explained by this model. Meanwhile, as one part of the general Circuit-Probability theory this model expand the probability calculation from a single equation, which is applied for the Circuit-Probability theory in our previous study, to a general form, which is a set of quantized operation.