New Results
Resource: Scalable whole genome sequencing of 40,000 single cells identifies stochastic aneuploidies, genome replication states and clonal repertoires
Emma Laks, Hans Zahn, Daniel Lai, Andrew McPherson, Adi Steif, Jazmine Brimhall, Justina Biele, Beixi Wang, Tehmina Masud, Diljot Grewal, Cydney Nielsen, Samantha Leung, Viktoria Bojilova, Maia Smith, Oleg Golovko, Steven Poon, Peter Eirew, Farhia Kabeer, Teresa Ruiz de Algara, So Ra Lee, M. Jafar Taghiyar, Curtis Huebner, Jessica Ngo, Tim Chan, Spencer Vatrt-Watts, Pascale Walters, Nafis Abrar, Sophia Chan, Matt Wiens, Lauren Martin, R. Wilder Scott, Michael T. Underhill, Elizabeth Chavez, Christian Steidl, Daniel Da Costa, Yusanne Ma, Robin J. N. Coope, Richard Corbett, Stephen Pleasance, Richard Moore, Andy J. Mungall, IMAXT Consortium, Marco A. Marra, Carl Hansen, Sohrab P. Shah, Samuel Aparicio
doi: https://doi.org/10.1101/411058
Emma Laks
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
3Genome Science and Technology Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada
Hans Zahn
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
3Genome Science and Technology Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada
4Centre for High Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Daniel Lai
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Andrew McPherson
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Adi Steif
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
3Genome Science and Technology Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada
Jazmine Brimhall
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Justina Biele
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Beixi Wang
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Tehmina Masud
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Diljot Grewal
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Cydney Nielsen
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Samantha Leung
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Viktoria Bojilova
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Maia Smith
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Oleg Golovko
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Steven Poon
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
Peter Eirew
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Farhia Kabeer
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Teresa Ruiz de Algara
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
So Ra Lee
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
M. Jafar Taghiyar
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Curtis Huebner
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Jessica Ngo
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Tim Chan
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Spencer Vatrt-Watts
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Pascale Walters
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Nafis Abrar
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Sophia Chan
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Matt Wiens
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Lauren Martin
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
R. Wilder Scott
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Michael T. Underhill
4Centre for High Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Elizabeth Chavez
7Centre for Lymphoid Cancer, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
Christian Steidl
7Centre for Lymphoid Cancer, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
Daniel Da Costa
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
4Centre for High Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Yusanne Ma
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Robin J. N. Coope
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Richard Corbett
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Stephen Pleasance
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Richard Moore
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Andy J. Mungall
5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
Marco A. Marra
6Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Carl Hansen
4Centre for High Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Sohrab P. Shah
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
8Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 417 East 68th St., New York, NY 10065, USA
Samuel Aparicio
1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
Article Information
History
- September 13, 2018.
Article Versions
- Version 1 (September 7, 2018 - 00:04).
- You are viewing Version 2, the most recent version of this article.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Emma Laks1,2,3,*,
- Hans Zahn1,3,4,*,
- Daniel Lai1,2,*,
- Andrew McPherson1,2,*,
- Adi Steif1,2,3,*,
- Jazmine Brimhall1,2,
- Justina Biele1,2,
- Beixi Wang1,2,
- Tehmina Masud1,2,
- Diljot Grewal1,2,
- Cydney Nielsen1,2,
- Samantha Leung1,2,
- Viktoria Bojilova1,2,
- Maia Smith1,2,
- Oleg Golovko1,2,
- Steven Poon1,
- Peter Eirew1,2,
- Farhia Kabeer1,2,
- Teresa Ruiz de Algara1,2,
- So Ra Lee1,2,
- M. Jafar Taghiyar1,2,
- Curtis Huebner1,2,
- Jessica Ngo1,2,
- Tim Chan1,2,
- Spencer Vatrt-Watts1,2,
- Pascale Walters1,2,
- Nafis Abrar1,2,
- Sophia Chan1,2,
- Matt Wiens1,2,
- Lauren Martin1,2,
- R. Wilder Scott1,2,
- Michael T. Underhill4,
- Elizabeth Chavez7,
- Christian Steidl7,
- Daniel Da Costa1,4,
- Yusanne Ma5,
- Robin J. N. Coope5,
- Richard Corbett5,
- Stephen Pleasance5,
- Richard Moore5,
- Andy J. Mungall5,
- IMAXT Consortium9,
- Marco A. Marra6,
- Carl Hansen4,
- Sohrab P. Shah1,2,8,+ and
- Samuel Aparicio1,2,+
- 1Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
- 2Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
- 3Genome Science and Technology Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada
- 4Centre for High Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
- 5Michael Smith Genome Sciences Centre, BC Cancer, Vancouver V5Z 1L3, Canada
- 6Department of Medical Genetics, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
- 7Centre for Lymphoid Cancer, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
- 8Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 417 East 68th St., New York, NY 10065, USA
- ↵+to whom correspondence should be addressed. sshah{at}bccrc.ca, saparicio{at}bccrc.ca
↵* equal contribution
Posted September 13, 2018.
Resource: Scalable whole genome sequencing of 40,000 single cells identifies stochastic aneuploidies, genome replication states and clonal repertoires
Emma Laks, Hans Zahn, Daniel Lai, Andrew McPherson, Adi Steif, Jazmine Brimhall, Justina Biele, Beixi Wang, Tehmina Masud, Diljot Grewal, Cydney Nielsen, Samantha Leung, Viktoria Bojilova, Maia Smith, Oleg Golovko, Steven Poon, Peter Eirew, Farhia Kabeer, Teresa Ruiz de Algara, So Ra Lee, M. Jafar Taghiyar, Curtis Huebner, Jessica Ngo, Tim Chan, Spencer Vatrt-Watts, Pascale Walters, Nafis Abrar, Sophia Chan, Matt Wiens, Lauren Martin, R. Wilder Scott, Michael T. Underhill, Elizabeth Chavez, Christian Steidl, Daniel Da Costa, Yusanne Ma, Robin J. N. Coope, Richard Corbett, Stephen Pleasance, Richard Moore, Andy J. Mungall, IMAXT Consortium, Marco A. Marra, Carl Hansen, Sohrab P. Shah, Samuel Aparicio
bioRxiv 411058; doi: https://doi.org/10.1101/411058
Resource: Scalable whole genome sequencing of 40,000 single cells identifies stochastic aneuploidies, genome replication states and clonal repertoires
Emma Laks, Hans Zahn, Daniel Lai, Andrew McPherson, Adi Steif, Jazmine Brimhall, Justina Biele, Beixi Wang, Tehmina Masud, Diljot Grewal, Cydney Nielsen, Samantha Leung, Viktoria Bojilova, Maia Smith, Oleg Golovko, Steven Poon, Peter Eirew, Farhia Kabeer, Teresa Ruiz de Algara, So Ra Lee, M. Jafar Taghiyar, Curtis Huebner, Jessica Ngo, Tim Chan, Spencer Vatrt-Watts, Pascale Walters, Nafis Abrar, Sophia Chan, Matt Wiens, Lauren Martin, R. Wilder Scott, Michael T. Underhill, Elizabeth Chavez, Christian Steidl, Daniel Da Costa, Yusanne Ma, Robin J. N. Coope, Richard Corbett, Stephen Pleasance, Richard Moore, Andy J. Mungall, IMAXT Consortium, Marco A. Marra, Carl Hansen, Sohrab P. Shah, Samuel Aparicio
bioRxiv 411058; doi: https://doi.org/10.1101/411058
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