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Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, View ORCID ProfileXuhui Huang
doi: https://doi.org/10.1101/2020.04.27.063859
Lu Zhang
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
Dong Zhang
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
Congmin Yuan
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
Xiaowei Wang
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
Yongfang Li
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
Xilin Jia
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
2University of Chinese Academy of Sciences, Beijing, China
Xin Gao
5Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences Engineering Division, King Abdullah University of Science and Technology, Saudi Arabia
Hui-Ling Yen
6School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
Peter Pak-Hang Cheung
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
Xuhui Huang
3Department of Chemistry, Centre of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong
4The Hong Kong University of Science and Technology-Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518057, China
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Posted July 10, 2020.
Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, Xuhui Huang
bioRxiv 2020.04.27.063859; doi: https://doi.org/10.1101/2020.04.27.063859
Role of 1’-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Lu Zhang, Dong Zhang, Congmin Yuan, Xiaowei Wang, Yongfang Li, Xilin Jia, Xin Gao, Hui-Ling Yen, Peter Pak-Hang Cheung, Xuhui Huang
bioRxiv 2020.04.27.063859; doi: https://doi.org/10.1101/2020.04.27.063859
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