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Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
David A. Lomas, View ORCID ProfileJames A. Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun-wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S. Holmes, Jonathan P. Hutchinson, Alistair Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J. Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, View ORCID ProfileRiccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J. Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C. Pearce
doi: https://doi.org/10.1101/2020.07.26.217661
David A. Lomas
1UCL Respiratory, Rayne Institute, University College London, London. WC1E 6JF
James A. Irving
1UCL Respiratory, Rayne Institute, University College London, London. WC1E 6JF
Christopher Arico-Muendel
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Svetlana Belyanskaya
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Andrew Brewster
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Murray Brown
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Chun-wa Chung
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Hitesh Dave
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Alexis Denis
4GlaxoSmithKline, Avenue du Quebec, Paris 91140
Nerina Dodic
4GlaxoSmithKline, Avenue du Quebec, Paris 91140
Anthony Dossang
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Peter Eddershaw
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Diana Klimaszewska
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Imran Haq
1UCL Respiratory, Rayne Institute, University College London, London. WC1E 6JF
Duncan S. Holmes
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Jonathan P. Hutchinson
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Alistair Jagger
1UCL Respiratory, Rayne Institute, University College London, London. WC1E 6JF
Toral Jakhria
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Emilie Jigorel
4GlaxoSmithKline, Avenue du Quebec, Paris 91140
John Liddle
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Ken Lind
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Stefan J. Marciniak
5Cambridge Institute for Medical Research, Hills Rd, Cambridge CB2 0XY
Jeff Messer
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Margaret Neu
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Allison Olszewski
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Adriana Ordonez
5Cambridge Institute for Medical Research, Hills Rd, Cambridge CB2 0XY
Riccardo Ronzoni
1UCL Respiratory, Rayne Institute, University College London, London. WC1E 6JF
James Rowedder
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Martin Rüdiger
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Steve Skinner
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Kathrine J. Smith
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Rebecca Terry
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Lionel Trottet
4GlaxoSmithKline, Avenue du Quebec, Paris 91140
Iain Uings
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Steve Wilson
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Zhengrong Zhu
2GlaxoSmithKline, Cambridge Park Drive, 6th floor, Cambridge, MA 02140
Andrew C. Pearce
3GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts. SG1 2NY
Article usage
Posted July 28, 2020.
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
David A. Lomas, James A. Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun-wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S. Holmes, Jonathan P. Hutchinson, Alistair Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J. Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J. Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C. Pearce
bioRxiv 2020.07.26.217661; doi: https://doi.org/10.1101/2020.07.26.217661
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
David A. Lomas, James A. Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun-wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S. Holmes, Jonathan P. Hutchinson, Alistair Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J. Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J. Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C. Pearce
bioRxiv 2020.07.26.217661; doi: https://doi.org/10.1101/2020.07.26.217661
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