New Results
Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function
View ORCID ProfileSudha Rajderkar, View ORCID ProfileIros Barozzi, Yiwen Zhu, Rong Hu, View ORCID ProfileYanxiao Zhang, Bin Li, Yoko Fukuda-Yuzawa, View ORCID ProfileGuy Kelman, Adyam Akeza, View ORCID ProfileMatthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, View ORCID ProfileStella Tran, Michael E. Talkowski, K. C. Kent Lloyd, View ORCID ProfileBing Ren, View ORCID ProfileDiane E. Dickel, View ORCID ProfileAxel Visel, View ORCID ProfileLen A. Pennacchio
doi: https://doi.org/10.1101/2021.05.06.443037
Sudha Rajderkar
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Iros Barozzi
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
2Institute of Cancer Research Medical University of Vienna, Borschkegasse 8a 1090, Vienna, Austria
3Department of Surgery and Cancer, Imperial College London, London, UK
Yiwen Zhu
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Rong Hu
4Ludwig Institute for Cancer Research, La Jolla, CA, USA
Yanxiao Zhang
4Ludwig Institute for Cancer Research, La Jolla, CA, USA
Bin Li
4Ludwig Institute for Cancer Research, La Jolla, CA, USA
Yoko Fukuda-Yuzawa
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
5Institute of Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
Guy Kelman
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
6The Jerusalem Center for Personalized Computational Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Adyam Akeza
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Matthew J. Blow
15U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA
Quan Pham
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Anne N. Harrington
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Janeth Godoy
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Eman M. Meky
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Kianna von Maydell
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Catherine S. Novak
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Ingrid Plajzer-Frick
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Veena Afzal
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Stella Tran
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Michael E. Talkowski
7Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
8Program in Medical and Population Genetics and Stanley Center for Psychiatric Disorders, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
9Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
K. C. Kent Lloyd
10Mouse Biology Program, University of California, Davis, Davis, California, USA
11Department of Surgery, School of Medicine, University of California, Davis, Davis, California, USA
Bing Ren
4Ludwig Institute for Cancer Research, La Jolla, CA, USA
12Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA
13Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
14Institute of Genome Medicine, Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA
Diane E. Dickel
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Axel Visel
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
15U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA
16School of Natural Sciences, University of California, Merced, Merced, California, USA
Len A. Pennacchio
1Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
15U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA
17Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA
Posted May 07, 2021.
Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function
Sudha Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Yoko Fukuda-Yuzawa, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, Stella Tran, Michael E. Talkowski, K. C. Kent Lloyd, Bing Ren, Diane E. Dickel, Axel Visel, Len A. Pennacchio
bioRxiv 2021.05.06.443037; doi: https://doi.org/10.1101/2021.05.06.443037
Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function
Sudha Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Yoko Fukuda-Yuzawa, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, Stella Tran, Michael E. Talkowski, K. C. Kent Lloyd, Bing Ren, Diane E. Dickel, Axel Visel, Len A. Pennacchio
bioRxiv 2021.05.06.443037; doi: https://doi.org/10.1101/2021.05.06.443037
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