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Human bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukaemia
Deepali Pal, Helen Blair, Sophie Boyd, Angel Hanmy Sharon, Salem Nizami, Asmida Isa, Melanie Beckett, Ryan Nelson, Aaron Wilson, Mankaran Singh, Shalini Sankar, Ricky Tirtakusuma, Nakjang Sirintra, Carly Knill, Andrew Fuller, Hesta McNeill, View ORCID ProfileLisa Russell, Claire Schwab, Peixun Zhous, Paul Sinclair, Jonathan Coxhead, Andrew Filby, Christina Halsey, James M. Allan, J. Christine Harrison, Anthony Moorman, Heidenreich Olaf, Josef Vormoor
doi: https://doi.org/10.1101/2021.06.18.448490
Deepali Pal
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
2Department of Applied Sciences, Room A105, Ellison Building, Northumbria University, Newcastle upon Tyne, NE1 8ST. UK
Helen Blair
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Sophie Boyd
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Angel Hanmy Sharon
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Salem Nizami
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Asmida Isa
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
7Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam 13200 Kepala Batas, Pulau Pinang, Malaysia
Melanie Beckett
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Ryan Nelson
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
3Princess Maxima Centrum for Pediatric Oncology, Heidelberglaan 25, 3584CS Utrecht. The Netherlands
Aaron Wilson
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Mankaran Singh
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Shalini Sankar
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Ricky Tirtakusuma
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Nakjang Sirintra
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Carly Knill
4Flow Cytometry Core Facility, Biosciences Institute, William Leech Building, 2nd floor Room M2.099, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH. UK
Andrew Fuller
4Flow Cytometry Core Facility, Biosciences Institute, William Leech Building, 2nd floor Room M2.099, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH. UK
Hesta McNeill
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Lisa Russell
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Claire Schwab
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Peixun Zhous
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Paul Sinclair
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Jonathan Coxhead
5Genomics Core Facility, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ. UK
Andrew Filby
4Flow Cytometry Core Facility, Biosciences Institute, William Leech Building, 2nd floor Room M2.099, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH. UK
Christina Halsey
6Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH. UK
James M. Allan
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
J. Christine Harrison
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Anthony Moorman
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
Heidenreich Olaf
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
3Princess Maxima Centrum for Pediatric Oncology, Heidelberglaan 25, 3584CS Utrecht. The Netherlands
Josef Vormoor
1Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Herschel Building Level 6, Brewery Lane, Newcastle upon Tyne, NE1 7RU. UK
3Princess Maxima Centrum for Pediatric Oncology, Heidelberglaan 25, 3584CS Utrecht. The Netherlands
9University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Nederland
Article usage
Posted June 21, 2022.
Human bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukaemia
Deepali Pal, Helen Blair, Sophie Boyd, Angel Hanmy Sharon, Salem Nizami, Asmida Isa, Melanie Beckett, Ryan Nelson, Aaron Wilson, Mankaran Singh, Shalini Sankar, Ricky Tirtakusuma, Nakjang Sirintra, Carly Knill, Andrew Fuller, Hesta McNeill, Lisa Russell, Claire Schwab, Peixun Zhous, Paul Sinclair, Jonathan Coxhead, Andrew Filby, Christina Halsey, James M. Allan, J. Christine Harrison, Anthony Moorman, Heidenreich Olaf, Josef Vormoor
bioRxiv 2021.06.18.448490; doi: https://doi.org/10.1101/2021.06.18.448490
Human bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukaemia
Deepali Pal, Helen Blair, Sophie Boyd, Angel Hanmy Sharon, Salem Nizami, Asmida Isa, Melanie Beckett, Ryan Nelson, Aaron Wilson, Mankaran Singh, Shalini Sankar, Ricky Tirtakusuma, Nakjang Sirintra, Carly Knill, Andrew Fuller, Hesta McNeill, Lisa Russell, Claire Schwab, Peixun Zhous, Paul Sinclair, Jonathan Coxhead, Andrew Filby, Christina Halsey, James M. Allan, J. Christine Harrison, Anthony Moorman, Heidenreich Olaf, Josef Vormoor
bioRxiv 2021.06.18.448490; doi: https://doi.org/10.1101/2021.06.18.448490
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