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Whole-brain in vivo base editing reverses autistic-like behaviors in mice
Weike Li, Jinlong Chen, Wanling Peng, Bo Yuan, Wenjian Han, Yiting Yuan, Zhenyu Xue, Jincheng Wang, Zhifang Chen, Shifang Shan, Shujia Zhu, Min Xu, Tianlin Cheng, Zilong Qiu
doi: https://doi.org/10.1101/2022.01.25.477781
Weike Li
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Jinlong Chen
2Institute of Pediatrics, Children’s Hospital, Institutes for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
Wanling Peng
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Bo Yuan
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Wenjian Han
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Yiting Yuan
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Zhenyu Xue
5Department of Anesthesiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Jincheng Wang
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Zhifang Chen
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Shifang Shan
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Shujia Zhu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Min Xu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Tianlin Cheng
2Institute of Pediatrics, Children’s Hospital, Institutes for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
Zilong Qiu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
3National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
4Clinical Neuroscience Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Posted January 25, 2022.
Whole-brain in vivo base editing reverses autistic-like behaviors in mice
Weike Li, Jinlong Chen, Wanling Peng, Bo Yuan, Wenjian Han, Yiting Yuan, Zhenyu Xue, Jincheng Wang, Zhifang Chen, Shifang Shan, Shujia Zhu, Min Xu, Tianlin Cheng, Zilong Qiu
bioRxiv 2022.01.25.477781; doi: https://doi.org/10.1101/2022.01.25.477781
Whole-brain in vivo base editing reverses autistic-like behaviors in mice
Weike Li, Jinlong Chen, Wanling Peng, Bo Yuan, Wenjian Han, Yiting Yuan, Zhenyu Xue, Jincheng Wang, Zhifang Chen, Shifang Shan, Shujia Zhu, Min Xu, Tianlin Cheng, Zilong Qiu
bioRxiv 2022.01.25.477781; doi: https://doi.org/10.1101/2022.01.25.477781
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