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Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome
Dongwon Lee, Wu Chen, Heet Naresh Kaku, Xinming Zhuo, Eugene S. Chao, Armand Soriano, Allen Kuncheria, Stephanie Flores, Joo Hyun Kim, Frank Rigo, Paymaan Jafar-nejad, Arthur L. Beaudet, Matthew S. Caudill, View ORCID ProfileMingshan Xue
doi: https://doi.org/10.1101/2022.06.18.496687
Dongwon Lee
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Wu Chen
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Heet Naresh Kaku
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Xinming Zhuo
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Eugene S. Chao
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Armand Soriano
4Ionis Pharmaceuticals, Carlsbad, California 92010, USA
Allen Kuncheria
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Stephanie Flores
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Joo Hyun Kim
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Frank Rigo
4Ionis Pharmaceuticals, Carlsbad, California 92010, USA
Paymaan Jafar-nejad
4Ionis Pharmaceuticals, Carlsbad, California 92010, USA
Arthur L. Beaudet
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Matthew S. Caudill
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
5Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
Mingshan Xue
1Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
2The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, Texas 77030, USA
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Article usage
Posted June 21, 2022.
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome
Dongwon Lee, Wu Chen, Heet Naresh Kaku, Xinming Zhuo, Eugene S. Chao, Armand Soriano, Allen Kuncheria, Stephanie Flores, Joo Hyun Kim, Frank Rigo, Paymaan Jafar-nejad, Arthur L. Beaudet, Matthew S. Caudill, Mingshan Xue
bioRxiv 2022.06.18.496687; doi: https://doi.org/10.1101/2022.06.18.496687
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome
Dongwon Lee, Wu Chen, Heet Naresh Kaku, Xinming Zhuo, Eugene S. Chao, Armand Soriano, Allen Kuncheria, Stephanie Flores, Joo Hyun Kim, Frank Rigo, Paymaan Jafar-nejad, Arthur L. Beaudet, Matthew S. Caudill, Mingshan Xue
bioRxiv 2022.06.18.496687; doi: https://doi.org/10.1101/2022.06.18.496687
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