Abstract
Summary Genozip performs compression of a wide range of genomic data, including widely used FASTQ, BAM and VCF file formats. Here, we introduce the latest advancement in Genozip technology, focused on compression of BAM and CRAM files. We demonstrate Genozip’s ability to compress data generated by a variety of study types (e.g., whole genome sequencing, DNA methylation, RNASeq), sequencing technologies and aligners, up to 2.7 times better than the current state of the art compressor, CRAM version 3.1.
Availability and implementation Genozip is freely available for academic research use and has been tested for Linux, Mac and Windows. Installation instructions are available at https://genozip.com/installing.html. A user manual is available at https://genozip.com/manual.html.
Supplementary information Supplementary data are available.
Competing Interest Statement
D.L. receives royalties from commercial users of Genozip.