A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

Daria Bulanova; Yevhen Akimov; Wojciech Senkowski; Jaana Oikkonen; Laura Gall-Mas; Sanna Timonen; Manar Elmadani; Johanna Hynninen; Sampsa Hautaniemi; Tero Aittokallio; Krister Wennerberg

doi:10.1101/2022.11.14.516369

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A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

View ORCID ProfileDaria Bulanova, Yevhen Akimov, Wojciech Senkowski, Jaana Oikkonen, Laura Gall-Mas, Sanna Timonen, Manar Elmadani, Johanna Hynninen, View ORCID ProfileSampsa Hautaniemi, Tero Aittokallio, Krister Wennerberg

doi: https://doi.org/10.1101/2022.11.14.516369

Daria Bulanova

1Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

2Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland

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ORCID record for Daria Bulanova
For correspondence: daria.bulanova@helsinki.fi

Yevhen Akimov

2Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland

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Wojciech Senkowski

1Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

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Jaana Oikkonen

3Research Program in Systems Oncology (ONCOSYS), University of Helsinki, Helsinki, Finland

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Laura Gall-Mas

1Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

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Sanna Timonen

2Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland

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Manar Elmadani

4Finnish Red Cross Blood Service, Helsinki, Finland

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Johanna Hynninen

5Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland

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Sampsa Hautaniemi

3Research Program in Systems Oncology (ONCOSYS), University of Helsinki, Helsinki, Finland

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ORCID record for Sampsa Hautaniemi

Tero Aittokallio

2Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland

6Institute for Cancer Research, Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway

7Oslo Centre for Biostatistics and Epidemiology (OCBE), University of Oslo, Oslo, Norway

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Krister Wennerberg

1Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark

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Posted November 16, 2022.

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A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

Daria Bulanova, Yevhen Akimov, Wojciech Senkowski, Jaana Oikkonen, Laura Gall-Mas, Sanna Timonen, Manar Elmadani, Johanna Hynninen, Sampsa Hautaniemi, Tero Aittokallio, Krister Wennerberg

bioRxiv 2022.11.14.516369; doi: https://doi.org/10.1101/2022.11.14.516369

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A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

Daria Bulanova, Yevhen Akimov, Wojciech Senkowski, Jaana Oikkonen, Laura Gall-Mas, Sanna Timonen, Manar Elmadani, Johanna Hynninen, Sampsa Hautaniemi, Tero Aittokallio, Krister Wennerberg

bioRxiv 2022.11.14.516369; doi: https://doi.org/10.1101/2022.11.14.516369

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