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Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons

Sarah A. McClymont, Paul W. Hook, Alexandra I. Soto, Xylena Reed, William D. Law, Samuel J. Kerans, Eric L. Waite, Nicole J. Briceno, Joey F. Thole, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszolek, Cedric D. Moore, Heng Zhu, Jennifer A. Akiyama, Diane E. Dickel, Axel Visel, Len A. Pennacchio, Owen A. Ross, Michael A. Beer, Andrew S. McCallion
doi: https://doi.org/10.1101/364257
Sarah A. McClymont
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Paul W. Hook
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Alexandra I. Soto
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
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Xylena Reed
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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William D. Law
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Samuel J. Kerans
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Eric L. Waite
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Nicole J. Briceno
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Joey F. Thole
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Michael G. Heckman
Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA.
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Nancy N. Diehl
Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA.
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Zbigniew K. Wszolek
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
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Cedric D. Moore
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Heng Zhu
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Jennifer A. Akiyama
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
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Diane E. Dickel
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
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Axel Visel
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.School of Natural Sciences, University of California, Merced, Merced, California, USA.
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Len A. Pennacchio
Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.Comparative Biochemistry Program, University of California, Berkeley, California, USA.
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Owen A. Ross
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.Mayo Graduate School, Neurobiology of Disease, Jacksonville, Florida, USA.Department of Clinical Genomics, Jacksonville, Florida, USA.
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Michael A. Beer
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Andrew S. McCallion
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.Department of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  • For correspondence: andy@jhmi.edu
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Article Information

doi 
https://doi.org/10.1101/364257
History 
  • July 8, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Sarah A. McClymont1,
  2. Paul W. Hook1,
  3. Alexandra I. Soto2,
  4. Xylena Reed1,
  5. William D. Law1,
  6. Samuel J. Kerans1,
  7. Eric L. Waite1,
  8. Nicole J. Briceno1,
  9. Joey F. Thole1,
  10. Michael G. Heckman3,
  11. Nancy N. Diehl3,
  12. Zbigniew K. Wszolek4,
  13. Cedric D. Moore5,
  14. Heng Zhu5,
  15. Jennifer A. Akiyama6,
  16. Diane E. Dickel6,
  17. Axel Visel6,7,8,
  18. Len A. Pennacchio6,7,9,
  19. Owen A. Ross2,10,11,
  20. Michael A. Beer1,12 and
  21. Andrew S. McCallion1,13,14,*
  1. 1McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  2. 2Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  3. 3Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA.
  4. 4Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  5. 5Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  6. 6Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
  7. 7US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.
  8. 8School of Natural Sciences, University of California, Merced, Merced, California, USA.
  9. 9Comparative Biochemistry Program, University of California, Berkeley, California, USA.
  10. 10Mayo Graduate School, Neurobiology of Disease, Jacksonville, Florida, USA.
  11. 11Department of Clinical Genomics, Jacksonville, Florida, USA.
  12. 12Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  13. 13Department of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  14. 14Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  1. ↵*To whom correspondence should be addressed: andy{at}jhmi.edu
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Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons
Sarah A. McClymont, Paul W. Hook, Alexandra I. Soto, Xylena Reed, William D. Law, Samuel J. Kerans, Eric L. Waite, Nicole J. Briceno, Joey F. Thole, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszolek, Cedric D. Moore, Heng Zhu, Jennifer A. Akiyama, Diane E. Dickel, Axel Visel, Len A. Pennacchio, Owen A. Ross, Michael A. Beer, Andrew S. McCallion
bioRxiv 364257; doi: https://doi.org/10.1101/364257
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Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons
Sarah A. McClymont, Paul W. Hook, Alexandra I. Soto, Xylena Reed, William D. Law, Samuel J. Kerans, Eric L. Waite, Nicole J. Briceno, Joey F. Thole, Michael G. Heckman, Nancy N. Diehl, Zbigniew K. Wszolek, Cedric D. Moore, Heng Zhu, Jennifer A. Akiyama, Diane E. Dickel, Axel Visel, Len A. Pennacchio, Owen A. Ross, Michael A. Beer, Andrew S. McCallion
bioRxiv 364257; doi: https://doi.org/10.1101/364257

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