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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease
View ORCID ProfileLaura J. Corbin, Amy E. Taylor, Stephen J. White, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G J Hazell, Lavinia Paternoster, Marcus R. Munafò, Børge G. Nordestgaard, Anne Tybjaerg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, for the GoDMC Consortium, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson
doi: https://doi.org/10.1101/473728
Laura J. Corbin
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Amy E. Taylor
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
3NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS8 2BN, UK
Stephen J. White
4School of Healthcare Science, Manchester Metropolitan University, Manchester, M15 6BH, UK
Christopher M. Williams
5School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Kurt Taylor
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Marion T. van den Bosch
5School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
6Genome Sciences Centre, British Columbia (BC) Cancer Agency, Vancouver, BC, V5Z 1L3, Canada
Jack E. Teasdale
7Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS2 8DZ, UK
Matthew Jones
7Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS2 8DZ, UK
Mark Bond
7Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS2 8DZ, UK
Matthew T. Harper
8Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD
Louise Falk
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Alix Groom
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Georgina G J Hazell
7Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS2 8DZ, UK
Lavinia Paternoster
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Marcus R. Munafò
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
9UK Centre for Tobacco and Alcohol Studies and School of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK
Børge G. Nordestgaard
10Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark
11Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
12The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, 2000, Denmark
Anne Tybjaerg-Hansen
11Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
12The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, 2000, Denmark
13Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark
Stig E. Bojesen
10Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark
11Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
12The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, 2000, Denmark
Caroline Relton
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Josine L. Min
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
George Davey Smith
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Andrew D. Mumford
14School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
Alastair W. Poole
5School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Nicholas J. Timpson
1MRC Integrative Epidemiology Unit at University of Bristol, Bristol, BS8 2BN, UK
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
Posted November 22, 2018.
Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease
Laura J. Corbin, Amy E. Taylor, Stephen J. White, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G J Hazell, Lavinia Paternoster, Marcus R. Munafò, Børge G. Nordestgaard, Anne Tybjaerg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, for the GoDMC Consortium, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson
bioRxiv 473728; doi: https://doi.org/10.1101/473728
Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease
Laura J. Corbin, Amy E. Taylor, Stephen J. White, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G J Hazell, Lavinia Paternoster, Marcus R. Munafò, Børge G. Nordestgaard, Anne Tybjaerg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, for the GoDMC Consortium, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson
bioRxiv 473728; doi: https://doi.org/10.1101/473728
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