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Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Laurie Herviou, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva Desmedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Karin Vanderkerken, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien, Jérôme Moreaux
doi: https://doi.org/10.1101/776930
Laurie Herviou
1IGH, CNRS, Univ Montpellier, France
2CHU Montpellier, Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier, France
4University of Montpellier, Montpellier, F-34090, France
Fanny Izard
3Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Institut Régional du Cancer (ICM), Montpellier F-34298, France
4University of Montpellier, Montpellier, F-34090, France
Ouissem Karmous-Gadacha
2CHU Montpellier, Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier, France
Claire Gourzones
1IGH, CNRS, Univ Montpellier, France
Celine Bellanger
1IGH, CNRS, Univ Montpellier, France
Eva Desmedt
5Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium
Anqi Ma
6Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States
Laure Vincent
7CHU Montpellier, Department of Clinical Hematology, Montpellier, France
Guillaume Cartron
4University of Montpellier, Montpellier, F-34090, France
7CHU Montpellier, Department of Clinical Hematology, Montpellier, France
Karin Vanderkerken
5Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium
Jian Jin
6Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States
Elke De Bruyne
5Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium
Charlotte Grimaud
3Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Institut Régional du Cancer (ICM), Montpellier F-34298, France
4University of Montpellier, Montpellier, F-34090, France
8Centre National de la Recherche Scientifique (CNRS), F-34293, Montpellier, France
Eric Julien
3Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Institut Régional du Cancer (ICM), Montpellier F-34298, France
4University of Montpellier, Montpellier, F-34090, France
8Centre National de la Recherche Scientifique (CNRS), F-34293, Montpellier, France
Jérôme Moreaux
1IGH, CNRS, Univ Montpellier, France
2CHU Montpellier, Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier, France
4University of Montpellier, Montpellier, F-34090, France
Article usage
Posted September 20, 2019.
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Laurie Herviou, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva Desmedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Karin Vanderkerken, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien, Jérôme Moreaux
bioRxiv 776930; doi: https://doi.org/10.1101/776930
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma
Laurie Herviou, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzones, Celine Bellanger, Eva Desmedt, Anqi Ma, Laure Vincent, Guillaume Cartron, Karin Vanderkerken, Jian Jin, Elke De Bruyne, Charlotte Grimaud, Eric Julien, Jérôme Moreaux
bioRxiv 776930; doi: https://doi.org/10.1101/776930
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